Lab Information Management (LIMS) for Cannabis Quality Assurance

As the cannabis testing industry grows more and more, so does the need for laboratories to be able to trust a professional LIMS (Laboratory Information Management System) to ensure accurate and speedy results, reports, regulatory compliance and the many other aspects of data management required.

LabLynx Press is pleased to announce our new book to help Cannabis laboratories with the evaluation and selection of all types of informatics applications for managing cannabis testing and quality assurance.  To download your free copy of the ebook or purchase the print edition, visit:  You can also read the book on-line and discuss content and ask questions within the discussion groups on LiMSforum.

The Complete Guide to LIMS & Laboratory Informatics: Summer 2017 Edition

LiMSwiki has just released the the latest LIMS and Lab Informatics Buyer’s Guide. 

This guide originally started in 2011 with 15 LIMS/LI vendors that included pricing for those vendors. Today’s edition has over 50 vendors including pricing and links to video demonstrations of their products. Also, there are comprehensive chapters to cover LIMS requirements and other educational information that is valuable for those seeking to learn more about LIMS in general.

Bioinformatics: Indispensable, yet hidden in plain sight?

This brief paper published in BMC Bioinformatics provides a sociological examination of the world of bioinformatics and how it’s perceived institutionally. Bartlett et al. argue that institutionally while less focus is place on bioinformatics processes and more on the data input and output, putting the contributions of bioinformaticists into a “black box,” losing scientific credit in the process. The researchers conclude that “[i]n the pursuit of relevance and impact, future scientific careers will increasingly involve playing the role of a fractional scientist … combining a variety of expertise and epistemic aspirations…” to become “tomorrow’s bioinformatic scientists.”

Global data quality assessment and the situated nature of “best” research practices in biology

In this 2017 journal article published in the Data Science Journal, data scientist Sabina Leonelli reflects on a paradigm shift in biology where “specific data production technologies [are used] as proxy for assessing data quality,” creating problems along the way, particularly for the open data movement. Leonelli’s major concern: “Ethnographic research carried out in such environments evidences a widespread fear among researchers that providing extensive information about their experimental set-up will affect the perceived quality of their data, making their findings vulnerable to criticisms by better-resourced peers,” hindering data and provenance sharing. And the conclusion? Endorsing specific data production and management technologies as indicators of data quality can cloud the goals of open data initiatives.

Neuroimaging, genetics, and clinical data sharing in Python using the CubicWeb framework

In this 2017 article published in Frontiers in Neuroinformatics, Grigis et al., like many before them, note that data in scientific areas of research such as genetics, imaging, and the social sciences has become “massive, heterogeneous, and complex.” Their solution is a Python-based one that integrates the CubicWeb open-source semantic framework and other tools “to overcome the challenges associated with data sharing and collaborative requirements” found in population imaging studies. The resulting data sharing service (DSS) proves to be flexible, integratable, and expandable based on demand, they conclude.

Analyzing the field of bioinformatics with the multi-faceted topic modeling technique

Wikipedia defines bibliometrics as a “statistical analysis of written publications, such as books or articles.” Related to information and library science, bibliometrics has been helping researchers make better sense of the trends and impacts made across numerous fields. In this 2017 paper, Heo et al. use bibliometric methods new and old to examine the field of bioinformatics via related journals over a period of 20 years to better understand how the field has changed in that time. They conclude that “the characteristics of the bioinformatics field become more distinct and more specific, and the supporting role of peripheral fields of bioinformatics, such as conceptual, mathematical, and systems biology, gradually increases over time, though the core fields of proteomics, genomics, and genetics are still the major topics.”

Intervene: A tool for intersection and visualization of multiple gene or genomic region sets

As Khan and Mathelier note in their abstract, one of the more common tasks of a bioinformatician is to take lists of genomes or genomic regions from high-throughput sequencing and compare them visually. Noting the lack of a comprehensive tool to visualize such complex datasets, the authors developed Intervene, a tool for computing intersections of multiple genomic and list sets. They conclude that “Intervene is the first tool to provide three types of visualization approaches for multiple sets of gene or genomic intervals,” and they have made the the source code, web app, and documentation freely available to the public.

Users’ perspectives on a picture archiving and communication system (PACS): An in-depth study in a teaching hospital in Kuwait

The picture archiving and communication system (PACS) is an increasingly important information management component of hospitals and medical centers, allowing for the digital acquisition, archiving, communication, retrieval, processing, distribution, and display of medical images. But do staff members using it find that a PACS makes their job easier and more effective? This journal article by Buabbas et al. represents another attempt by medical researchers to quantify and qualify the impact of the PACS on radiologists and technologists using the system. In their case, the authors concluded that “[d]espite some of the technical limitations of the infrastructure, most of the respondents rated the system positively and as user-friendly” but, like any information system, there are still a few areas of improvement that need attention.

Effective information extraction framework for heterogeneous clinical reports using online machine learning and controlled vocabularies

Even in the digital realm (think electronic medical records), extracting usable information from narrated medical reports can be a challenge given heterogeneous data structures and vocabularies. While many systems have been created over the years to tackle this task, researchers from Emory and Stony Brook University have taken a different approach: online learning. Here Zheng et al. present their methodology and findings associated with their Information and Data Extraction using Adaptive Online Learning (IDEAL-X) system, concluding that “the online learning–based method combined with controlled vocabularies for data extraction from reports with various structural patterns … is highly effective.”

Selecting a laboratory information management system for biorepositories in low- and middle-income countries: The H3Africa experience and lessons learned

What’s important for a biorepository laboratory information management system (LIMS), and what options are out there? What unique constraints in Africa make that selection more difficult? This brief 2017 paper from the Human Heredity and Health in Africa (H3Africa) Consortium outlines their take on finding the right LIMS solution for three of their regional biorepositories in Africa. The group emphasizes in the end that “[c]hoosing a LIMS in low- and middle-income countries requires careful consideration of the various factors that could affect its successful and sustainable deployment and use.”

Baobab Laboratory Information Management System: Development of an open-source laboratory information management system for biobanking

This journal article, published in Biopreservation and Biobanking in early 2017, presents the development philosophy and implementation of a custom-modified version of Bika LIMS called Baobab LIMS, designed for biobank clients and researchers. Bendou et al., who enlisted customization help directly from Bika Lab System, describe how “[t]he need to implement biobank standard operation procedures as well as stimulate the use of standards for biobank data representation motivated the implementation of Baobab LIMS, an open-source LIMS for biobanking.” The group concludes that while the open-source LIMS is quite usable as is, it will require further development of more “generic and configurable workflows.” Despite this, the authors anticipate the software to be useful to the biobanking community.

The FAIR Guiding Principles for scientific data management and stewardship

Most scientists know that much of the data created in academic research efforts ends up being locked away in silos, difficult to share with others. But what are scientists doing about? In this 2016 paper published in Scientific Data, Wilkinson et al. outline a distinct set of principles created towards reducing the silos of information: the FAIR Principles. The authors state the primary goal of the FAIR Principles is to “put specific emphasis on enhancing the ability of machines to automatically find and use the data, in addition to supporting its reuse by individuals.” After describing the principles and giving examples of projects that adhere to them, the authors conclude that the principles have the potential to “guide the implementation of the most basic levels of good Data Management and Stewardship practice, thus helping researchers adhere to the expectations and requirements of their funding agencies.”

A multi-service data management platform for scientific oceanographic products

The problem? Disparate data sources, from weather and wave forecasts to navigation charts and natural hazard assessments, made oceanography research in Southern Italy more cumbersome. Solution? Create a secure, standardized, and interoperable data platform that can merge all that and other information together into one powerful and easy-to-use platform. Thus the TESSA (Development of Technology for Situational Sea Awareness) program was born. D’Anca et al. discuss the creation and use of TESSA as a geospatial tool that merges real-time and archived data to help researchers in Southern Italy. The authors conclude that TESSA is “a valid prototype easily adopted to provide an efficient dissemination of maritime data and a consolidation of the management of operational oceanographic activities,” even in other parts of the world.

MASTR-MS: A web-based collaborative laboratory information management system (LIMS) for metabolomics

In development since at least the summer of 2009, the open-source MASTR-MS laboratory information management system (LIMS) was designed to better handle the data and metadata of metabolomics, the study of an entity’s metabolites. In this 2017 paper published in Metabolomics, the development team of MASTR-MS discuss the current state of their LIMS, how it’s being used, and what the future holds for it. They conclude by stating the software’s “comprehensive functions and features enable researchers and facilities to effectively manage a wide range of different project and experimental data types, and it facilitate the mining of new and existing [metabolomic] datasets.”

The effect of a test ordering software intervention on the prescription of unnecessary laboratory tests – A randomized controlled trial

When designing something as simple as a menu of laboratory tests into a piece of clinical software, it’s relatively easy to not think of the ramifications of the contents of such a menu. In this 2017 article published in BMC Medical Informatics and Decision Making, Martins et al. argue that there are consequences to what’s included in a laboratory test drop-down menu, primarily that the presence — or lack thereof — of a test type may influence how frequently that test is prescribed. The group concludes that “[r]emoving unnecessary tests from a quick shortcut menu of the diagnosis and laboratory tests ordering system had a significant impact and reduced unnecessary prescription of tests,” which in turn led “to the reduction of negative patient effects and to the reduction of unnecessary costs.”

The state of open-source electronic health record projects: A software anthropology study

In this journal article published in JMIR Medical Informatics in 2017, Alsaffar et al. review research from mid-2014 that looked at the state of open-source electronic health record (EHR) systems, primarily via SourceForge. The authors, noting a lack of research concerning the demographics and motivation of open-source EHR projects, present their finding, concluding that “lack of a corporate entity in most F/OSS EHR projects translates to a marginal capacity to market the respective F/OSS system and to navigate [HITECH] certification.”

PCM-SABRE: A platform for benchmarking and comparing outcome prediction methods in precision cancer medicine

In this 2017 paper published in BMC Bioinformatics, Eyal-Altman et al. explain the use and benefits of their KNIME-based cancer outcome analysis software PCM-SABRE (Precision Cancer Medicine – Survival Analysis Benchmarking, Reporting and Evaluation). The group demonstrates its effectiveness by reconstructing the previous work of Chou et al. and showing how the results necessitate the tool for better reproducibility. The researchers conclude that when used effectively, PCM-Sabre’s “resulting pipeline can be shared with others in an intuitive yet executable way, which will improve, if adopted by other investigators, the comparability and interpretability of future works attempting to predict patient survival from gene expression data.”

Ten simple rules for cultivating open science and collaborative R&D

This journal article in PLOS Computational Biology‘s long-running Ten Simple Rules series goes back to 2013, when a collaborative group of eight authors from around the globe pooled their thoughts together on the topic of open science and collaborative R&D. The conversations (linked to in this article) provide context and insight into the various projects — from the Gene Wiki initiative to the Open Source Drug Discovery (OSDD) project — that have required significant deviation of thought from the traditional company view of conducting business. From “lead as a coach, not a CEO” to “grow the commons,” the article’s authors provide their thoughts on what best makes for collaborative and open science projects.

Ten simple rules to enable multi-site collaborations through data sharing

In yet another installment of PLOS Computational Biology‘s Ten Simple Rules series, Boland et al. of Columbia University and the Broad Institute of MIT and Harvard share their thoughts and experiences with multi-site collaborations and data sharing. The group provides practical tips for making data sharing easier and more successful, strengthening collaborations and the scientific process.

Ten simple rules for developing usable software in computational biology

This is another entry in PLOS Computational Biology‘s long-running Ten Simple Rules series, which attempts to break down computational biology / bioinformatics topics (that relate to the informatics side) down into a digestible and cited format. This 2017 entry by List et al. looks at the typical problems associated with computational biology software development and attempts to provide a clear approach for more usable, efficient software. The authors conclude that despite following these 10 rules, there’s more to be done: “…effort is required from both users and developers to further improve a tool. Even engaging with only a few users … is likely to have a large impact on usability.”

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