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Annular elastolytic giant-cell granuloma (also known as "Giant cell elastophagocytosis,"[1] "Meischer's granuloma,"[2] "Miescher's granuloma of the face"[1]) is a cutaneous condition characterized histologically by a dermal infiltrate of macrophages.[1][2]: 706
| Annular elastolytic giant-cell granuloma | |
|---|---|
| Specialty | Dermatology  |
Signs and symptoms
The most common presentation of annular elastolytic giant-cell granuloma is one or more annular or ring-shaped patches with elevated borders, atrophy, and central hypopigmentation. Generalized papular lesions may also be observed.[3][4] Although it sporadically affects covered areas as well, annular elastolytic giant-cell granuloma is generally thought to be a disease that primarily affects sun-exposed areas.[5][6]
Diagnosis
Histopathologically, an annular elastolytic giant-cell granuloma exhibits a granulomatous reaction accompanied by phagocytosis of the elastic fibers, elastolysis, and multinucleate giant cells devoid of or reduced in elastin fibers. Other hallmarks of the histopathology include the lack of mucin deposition and collagen necrobiosis.[7]
Treatment
The handling of these cases is debatable, with differing results from topical treatments using tacrolimus, retinoids, and corticosteroids, and systemic treatments using methotrexate, isotretinoin, clofazimine, acitretin, and hydroxychloroquine.[8]
See also
References
- ^ a b c Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- ^ a b James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
- ^ Özkaya-Bayazit; Büyükbabani̇; Baykal; Öztürk; Okçu; Soyer (1999). "Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine". British Journal of Dermatology. 140 (3). Oxford University Press (OUP): 525–530. doi:10.1046/j.1365-2133.1999.02723.x. ISSN 0007-0963. PMID 10233280. S2CID 23145183.
- ^ Rongioletti, F.; Baldari, M.; Burlando, M.; Parodi, A. (2010). "Papular elastolytic giant cell granuloma: report of a case associated with monoclonal gammopathy and responsive to topical tacrolimus". Clinical and Experimental Dermatology. 35 (2). Oxford University Press (OUP): 145–148. doi:10.1111/j.1365-2230.2008.03129.x. ISSN 0307-6938. PMID 19508563. S2CID 19674767.
- ^ Ishibashi, Akira; Yokoyama, Aiko; Hirano, Kyoko (1987). "Annular Elastolytic Giant Cell Granuloma Occurring in Covered Areas". Dermatology. 174 (6). S. Karger AG: 293–297. doi:10.1159/000249202. ISSN 1018-8665. PMID 3622881.
- ^ Muramatsu, Tsutomu; Shirai, Toshihiko; Yamashina, Yukio; Sakamoto, Kuniki (1987). "Annular Elastolytic Giant Cell Granuloma: An Unusual Case with Lesions Arising in Non-sun-exposed Areas". The Journal of Dermatology. 14 (1). Wiley: 54–58. doi:10.1111/j.1346-8138.1987.tb02996.x. ISSN 0385-2407. PMID 3301949. S2CID 31861362.
- ^ Arora, Sandeep; Malik, Ajay; Patil, Chetan; Balki, Anil (2015). "Annular elastolytic giant cell granuloma: A report of 10 cases". Indian Dermatology Online Journal. 6 (7). Medknow: S17-20. doi:10.4103/2229-5178.171055. ISSN 2229-5178. PMC 4738508. PMID 26904442.
- ^ Babuna, Goncagul; Buyukbabani, Nesimi; Yazganoglu, KDidem; Baykal, Can (2011). "Effective treatment with hydroxychloroquine in a case of annular elastolytic giant cell granuloma". Indian Journal of Dermatology, Venereology and Leprology. 77 (1). Scientific Scholar: 110–111. doi:10.4103/0378-6323.74988. ISSN 0378-6323. PMID 21220900.
