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Ethan Menahem Shevach (born 1943[1]) is an immunologist at the National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, Maryland.

Ethan M. Shevach
Born1943
CitizenshipUnited States
EducationBoston University Medical School (MD 1967)
Known forregulatory T cells
AwardsWilliam B. Coley Award (2004)
Scientific career
Fieldsimmunology
InstitutionsNIAID

Biography

Shevach obtained his M.D. from Boston University Medical School in 1967. After clinical training, he joined NIAID as a senior staff fellow in 1972 becoming head of a research group the following year and a departmental head (section chief) in 1987. As of 2018, he is head of the Department of Cellular Immunology at NIAID.[2]

Shevach served as editor-in-chief of the Journal of Immunology from 1987 to 1992[3] and edited Cellular Immunology from 1996 to 2007.[2]

Research

Shevach made significant contributions towards understanding the function of regulatory T cells (TReg cells) in mediating the immune response. He discovered a subset of CD4+ T cells that express the transcription factor FOXP3 and operate by a mechanism that is distinct from the cytokine cascade.[4] Known as TReg cells, their primary function is immunosuppressive.[2] These TReg cells are targets for therapies against autoimmune diseases, cancer, and transplanted tissue rejection.[5]

Awards

He has been a member of the American Association of Immunologists since 1973 and received its Distinguished Service Award in 1992.[3]

In 2004, together with Shimon Sakaguchi, he won the Cancer Research Institute's William B. Coley Award for Distinguished Research in Basic and Tumor Immunology for his part in elucidating the function of regulatory T cells in the control of autoimmune diseases.[4]

Since 2015, Thomson Reuters (now Clarivate) has listed Shevach as among those most likely to win a Nobel Prize, based on his citation record.[6]

References

  1. ^ "ISNI 0000000081982771 Ethan M. Shevach (1943-)". ISNI. Retrieved 16 October 2018.
  2. ^ a b c "Ethan Shevach, M.D." NIH: National Institute of Allergy and Infectious Diseases. 18 November 2016. Retrieved 16 October 2018.
  3. ^ a b "Ethan M. Shevach". The American Association of Immunologists. 16 December 2015. Retrieved 16 October 2018.
  4. ^ a b "William B. Coley Award". Cancer Research Institute. Retrieved 16 October 2018.
  5. ^ Miyara, Makoto; Gorochov, Guy; Ehrenstein, Michael; Musset, Lucile; Sakaguchi, Shimon; Amoura, Zahir (2011). "Human FoxP3+ regulatory T cells in systemic autoimmune diseases". Autoimmunity Reviews. 10 (12): 744–755. doi:10.1016/j.autrev.2011.05.004. ISSN 1568-9972. PMID 21621000.
  6. ^ "2015 Citation Laureates Infographic". sciencewatch.com. 1 October 2015. Archived from the original on 1 October 2015. Retrieved 16 October 2018.