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Hiroshi Maeda (前田浩, Maeda Hiroshi, 22 December 1938 – 18 May 2021[1]) was a Japanese pharmacologist and chemist. He was known for his discovery of EPR effect. He published more than 650 papers in reputed journals; the h-index is 115 (Google scholar, As of 2022).[2]
Hiroshi Maeda | |
|---|---|
| Born | 前田 浩 December 22, 1938 Hyōgo Prefecture, Japan |
| Died | May 18, 2021 (aged 82) Kumamoto, Japan |
| Nationality | Japanese |
| Alma mater | Tohoku University University of California, Davis |
| Known for | EPR effect |
| Awards | Princess Takamatsu Cancer Research Fund Prizes Clarivate Citation Laureates (2016) |
| Scientific career | |
| Fields | Chemistry |
| Institutions | Sojo University Kumamoto University Harvard University |
Education and career
Maeda studied at Tohoku University with a bachelor's degree in 1962, at the University of California, Davis with a master's degree in 1964, and a doctorate in 1967 at Tohoku. He was a post-doctoral at the Sidney Farber Cancer Institute of Harvard University from 1967 to 1971, he also acquired the medical doctorate there.
From 1971 to 1980 he was an assistant professor at Kumamoto University and became a professor from 1980.
Research
Maeda developed the neocarzinostatin "SMANCS" with a copolymer of styrene and maleic acid in 1979. Afterward, Maeda and his student Yasuhiro Matsumura discovered the Enhanced permeability and retention effect (ERP effect) of macromolecular drugs in 1986, which laid an important foundation for the cancer-targeted therapy (CAncer Stromal Targeting; CAST).[3]
Recognition
Maeda was awarded Princess Takamatsu Cancer Research Fund Prizes, Commemorative Gold Medal of E.K.Frey-E.Werle, Life Time Achievement Award of Royal Pharmaceutical Society, CRS College of Fellows Award, Nagai Innovation Award for Outstanding Achievement (2013), and Clarivate Citation Laureates (2016).[4]
He was also a member of Controlled Release Society.
References
- ^ 熊本大名誉教授の前田浩さん死去 抗がん剤研究でノーベル賞有力候補 ８２歳 (in Japanese)
- ^ Hiroshi Maeda publications indexed by Google Scholar
- ^ Matsumura, Y; Maeda, H (1986). "A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs". Cancer Research. 46 (12): 6387–6392. PMID 2946403. Retrieved 29 September 2016.
- ^ 前田 浩 Hiroshi Maeda | Chem-Station (ケムステ)
