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COL16A1
Identifiers
Aliases	COL16A1, 447AA, FP1572, collagen type XVI alpha 1, collagen type XVI alpha 1 chain
External IDs	OMIM: 120326 MGI: 1095396 HomoloGene: 1397 GeneCards: COL16A1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	31,704,319 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	129,993,076 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	1307
	107581
	ENSG00000084636
	ENSMUSG00000040690
	Q07092
	Q8BLX7
	NM_001856
	NM_028266
	NP_001847
	NP_082542; NP_001391281; NP_001391282
	Wikidata
View/Edit Human	View/Edit Mouse

Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene.^[5]^[6]

Function

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000084636 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040690 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML (Aug 1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen". Proc Natl Acad Sci U S A. 89 (14): 6565–9. Bibcode:1992PNAS...89.6565P. doi:10.1073/pnas.89.14.6565. PMC 49542. PMID 1631157.
^ ^a ^b "Entrez Gene: COL16A1 collagen, type XVI, alpha 1".

Yamaguchi N, Kimura S, McBride OW, Hori H, Yamada Y, Kanamori T, Yamakoshi H, Nagai Y (1993). "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments". J. Biochem. 112 (6): 856–63. doi:10.1093/oxfordjournals.jbchem.a123989. PMID 1284248.
Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells". Matrix Biology. 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976.
Sires UI, Dublet B, Aubert-Foucher E, van der Rest M, Welgus HG (1995). "Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase". J. Biol. Chem. 270 (3): 1062–7. doi:10.1074/jbc.270.3.1062. PMID 7836360.
Tillet E, Mann K, Nischt R, Pan TC, Chu ML, Timpl R (1995). "Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain". Eur. J. Biochem. 228 (1): 160–8. doi:10.1111/j.1432-1033.1995.tb20245.x. PMID 7882999.
Grässel S, Timpl R, Tan EM, Chu ML (1997). "Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells". Eur. J. Biochem. 242 (3): 576–84. doi:10.1111/j.1432-1033.1996.0576r.x. PMID 9022684.
Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (March 2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells". Matrix Biology. 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976.
Kassner A, Hansen U, Miosge N, Reinhardt DP, Aigner T, Bruckner-Tuderman L, Bruckner P, Grässel S (2004). "Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils". Matrix Biol. 22 (2): 131–43. doi:10.1016/S0945-053X(03)00008-8. PMID 12782140.
Kassner A, Tiedemann K, Notbohm H, Ludwig T, Mörgelin M, Reinhardt DP, Chu ML, Bruckner P, Grässel S (2004). "Molecular structure and interaction of recombinant human type XVI collagen". J. Mol. Biol. 339 (4): 835–53. doi:10.1016/j.jmb.2004.03.042. PMID 15165854.
Eble JA, Kassner A, Niland S, Mörgelin M, Grifka J, Grässel S (2006). "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains". J. Biol. Chem. 281 (35): 25745–56. doi:10.1074/jbc.M509942200. PMID 16754661.

External links

"COL16A1 (collagen, type XVI, alpha 1)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000084636 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040690 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1631157-5] Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML (Aug 1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen". Proc Natl Acad Sci U S A. 89 (14): 6565–9. Bibcode:1992PNAS...89.6565P. doi:10.1073/pnas.89.14.6565. PMC 49542. PMID 1631157.

[entrez-6] "Entrez Gene: COL16A1 collagen, type XVI, alpha 1".

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Informatics Educational Institutions & Programs

Function

References

Further reading

External links