Reactive perforating collagenosis
SpecialtyDermatology Edit this on Wikidata

Reactive perforating collagenosis is a rare, familial, nonpuritic skin disorder characterized by papules that grow in a diameter of 4 to 6mm and develop a central area of umbilication to which keratinous material is lodged.[1][2] The cause of reactive perforating collagenosis is unknown.

Clinical Features

Inherited form

Keratotic papules measuring 1 to 6 mm develop on the extensor surface of the hands, the elbows, and the knees following superficial trauma. These lesions are painless. They appear as pin-sized lesions that grow to a papule of about 6mm in the following 3-5 weeks. They undergo spontaneous resolution in about 6-8 weeks leaving residual scarring. Lesions may recur throughout life. Cold weather is one of the factors known to trigger reccurences.[3]

Acquired form

In this form, keratotic papules develop on the trunk and extremities. These are commonly associated with pruritus. Lesions may or may not be related to superficial trauma.[3]

See also


  1. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Page 510. ISBN 0-7216-2921-0.
  2. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  3. ^ a b Ngan, Vanessa; Writer, Staff (2005). "Reactive perforating collagenosis". DermNet NZ. Retrieved 30 June 2021.

External links