Webinar: Optimizing Patient Blood Management: The Role of the Laboratory

"atient Blood Management (PBM) as defined by the Society for the Advancement of Blood Management refers to “the timely application of evidence-based medical and surgical concepts designed to maintain hemoglobin concentration, optimize hemostasis and minimize blood loss in an effort to improve patient outcome”.

Although the World Health Organization endorsed PBM in 2010, many hospitals still seek guidance with the implementation of PBM in clinical routine which goes beyond blood transfusion.

A review of the literature demonstrates that the role of the clinical laboratory in the multidisciplinary concept of PBM is underrepresented.

The speaker will explore the important role of the clinical laboratory and how it can impact each of the PBM pillars: from detecting anemia and iron deficiency to reducing blood loss."

Webinar: Sustainability Today for the Lab of Tomorrow

"Every purchasing decision you make for your lab today impacts the environmental story you’ll tell tomorrow. Labs are notorious for draining energy, single-use plastics, and tossing harmful chemicals into the air we breathe. By learning what makes lab equipment sustainable, and the features and materials to look for, you can begin to make decisions that have a lasting impact on the environment and labs’ overall footprint.

Learning Objectives

* Learn the methods and potential impact of embedding sustainability into your lab and facility plans.
* Learn what makes lab equipment sustainable.
* Learn the features to look for in order to make responsible purchase decisions."

Webinar: CAP Guidelines for Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies

"This webinar describes methods that are recommended to standardize the detection and measurement of the monoclonal proteins in different laboratories for the detection and initial diagnosis of monoclonal gammopathies. A monoclonal gammopathy is any disorder marked by proliferation of an abnormal clone (or clones) of a plasma cell or B cell in the bone marrow resulting in an abnormal increase of proteins in the blood serum and urine."

Webinar: COVID-19 Pandemic: Emerging Testing Solutions

"SARS-CoV-2 causes COVID-19, a potentially lethal viral infection that can cause severe pneumonia, long-term adverse effects to several organ systems, and death in some individuals. Since the infection was first reported at the end of 2019, the entire world has endured widespread infection and the global diagnostics and biopharmaceutical industries have mobilized to create diagnostic tests, antiviral drugs, and vaccines to help combat this global pandemic. The objectives of this presentation are (1) to provide an update on the COVID-19 pandemic, (2) to discuss SARS-CoV-2 variants with respect to both spread and virulence, (3) to review the current SARS-CoV-2 vaccines in terms of both efficacy and limitations, and (4) to review the types of SARS-CoV-2 tests that are available. The final part of the presentation will review what has been most important during the first two years of the pandemic and discuss what will be most important going forward. The overall goal is for the audience to have an up-to-date understanding of the epidemiology, virology, vaccination, and testing for SARS-CoV-2 and COVID-19 and what to look forward to in the coming year as we work together to manage this very serious challenge to global health."

Webinar: Responding to SARS-CoV-2 Variants, such as Omicron: Detection and Surveillance

"Since the initial COVID-19 outbreak, the SARS-CoV-2 virus has mutated, resulting in a range of variants. SARS-CoV-2 variants of concern, exemplified most recently with Omicron, need to be detected early and accurately to ensure confidence in testing results and surveillance efforts. In this webinar, we’ll discuss Thermo Fisher Scientific’s response and capabilities in the ongoing fight against COVID-19. This includes an overview of the current pandemic state, the PCR-based TaqPath COVID-19 diagnostic solution assay design, the S gene target failure, and surveillance solutions in light of Omicron. We will present the current knowledge on the features of the Omicron variant and showcase different strategies that were used around the world to track its spread.

We will further discuss the different approaches for detection, discrimination, and identification of novel SARS-CoV-2 variants using genetic tests. The webinar will provide an overview of surveillance tools which can enable laboratories to scale up surveillance testing and efficiently utilize available resources to fight the ongoing COVID-19 pandemic. In a time when getting answers quickly is critical, Thermo Fisher Scientific is leveraging its scale and resources to help the world move forward."

Webinar: COSMIC: Combining expert-curation with scientific innovation in a gold-standard database for precision oncology

"Key to precision oncology is the development of expert databases that organize and standardize information on cancer-related genetic variants, as well as their associated diagnostic, prognostic, and therapeutic implications, in a way that is easily accessible to multiple users. COSMIC, the Catalogue of Somatic Mutations in Cancer, was established nearly 20 years ago, and has been a gold-standard resource for this dataever since. Today, COSMIC is used on a daily basis in research labs, cancer centers, biotech, and pharmaceutical companies, where it comes into play as one of the keytrusted sources to analyze genomic data.

In this webinar, Dr. Zbyslaw Sondka, COSMIC’s Senior Scientist, and Rebecca White, COSMIC’s Scientific Communications Manager, will walk you through 3 key-aspects of the industry leading somatic mutation database."

Webinar: Oncotopix Discovery: deep learning as a standard analysis method for digital pathology images

"Easy-to-use AI-based deep learning is now integrated as the standard analysis methodology in our best-in-class analysis software. Designed for anyone, it allows tissue-based researchers to tackle both simple and complex datasets across a wide variety of applications. In the past, only image analysis experts could analyse complex tissues. Our new analysis packages include powerful pre-trained nuclei segmentation algorithms suitable for brightfield and fluorescence applications which can be further tuned for even more specificity, and deep-learning-based tissue segmentation to find tissues of interest, exclude artifacts, and enable scoring/counting within specific tissue compartments. Now, anyone with the understanding of tissue morphology can train an AI-based deep learning network to get accurate and reproducible data, making it easy to generate reliable quantitative results needed for breakthrough discoveries and publications."

Webinar: Data Integrity and Connectivity for Lab Balances

"Register to this free webinar to learn how data integrity problems can be prevented in the lab and what are the connectivity requirements for a modern laboratory balance. Data integrity is one of the most important criteria for reliable laboratory results and a hot topic for regulators and auditors. The increased use of electronic data and computerized systems has introduced new challenges in maintaining data integrity, especially for essential analytical instruments such as laboratory balances. In this webinar, we will use examples from FDA warning letters to explain typical compliance issues and how they can be prevented with a modern laboratory balance and digitalization."

Webinar: Demystifying machine learning: driving image analysis using your biological knowledge

"Machine learning (ML) offers many benefits to researchers using a wide range of microscopy techniques. Easier workflows, segmentation of difficult to detect objects, and the ability to adapt as imaging and experiment conditions change are a few examples. These benefits enable researchers to focus on obtaining the insights that power scientific discovery.

One hurdle that impacts the adoption of ML in image analysis workflows stems from the misconception that ML tools are difficult to understand and complex to deploy. In this webinar, Aivia expert Quyen Tran, PhD, will tackle ML fundamentals and how to effectively deploy machine-learning in cancer and cell biology research."

Webinar: Applications of multiplex digital PCR: Monitoring wastewater for SARS-CoV-2 and measuring bacterial gene expression

"Digital PCR is a specialized tool for nucleic acid quantification, which has applications in many research areas including those in microbiology and virology research. Leveraging optical multiplexing, multiple targets expected within a single sample can be tested in a single digital PCR reaction, providing absolute quantification without the need for a reference or standard curve.

In this webinar, invited speaker Dr. Joan L. Slonczewski of Kenyon College will describe their ongoing research, which leverages digital PCR."

Webinar: The COVID-19 Public Health Experience: Tales from the Lab

"Once upon a time, there were three public health labs. These labs were busy serving their states when, out of nowhere, a novel coronavirus emerged. Armed only with their existing staff, wits, energy, and knowledge, they sought to navigate a perilous landscape of ever-changing political and public requests while fighting the novel coronavirus, SARS-CoV-2. In this talk, three speakers will share their perspectives on the public health COVID-19 response to testing demand. Speaking from their state-specific perspectives, they will address the needs and challenges they faced in the realms of molecular, serology, and point-of-care testing. To conclude, speakers will highlight lessons learned as well as their hope that implementation of their recommendations will help with future pandemic preparedness."

Webinar: Automated sample preparation for reproducible clinical proteomics

"Mass spectrometry (MS)-based proteomic technologies are increasingly applied in a clinical context for disease classification and diagnostics, however their standardized use is still prevented by several bottlenecks in sample handling. Here, I will present how we integrated AFA-based ultrasonication in an automated proteomic workflow to enable routine, robust and comprehensive proteome analysis with minimal hands-on time. This can be applied to cells, fresh tissue and FFPE tissue, thus spanning the full range of clinical sample types and indicating universal utility. Moreover, 96 samples can be processed simultaneously, ensuring throughput under standardized conditions. Sensitivity of the approach will be shown from low-input experiments starting from 100-1000 cells. Data will be shown of the implementation of this pipeline to a cohort of 96 ependymoma tumor samples, where we integrated the obtained proteomic data with other omics layers allowing individualized molecular profiling and disease sub-classification."

Webinar: How and Why to Enter the Digital Laboratory

"2020 & 2021 have shown us how important digital solutions have become to enable collaboration and to work remotely. With less access to the lab and your colleagues, the move to digital tools is even more important.

In this On Demand webinar you will be given an introduction to where the digital lab space can become a reality for you and how to begin your digital transformation.

We will cover the areas where digitization will improve your workflow and sample safety, giving you more time to focus on what is important. Your Science!"

Webinar: Human vs. AI: Why manual curation is irreplaceable in clinical genomics

"Artificial intelligence (AI) is currently a buzzword across almost all scientific disciplines and has the potential to revolutionize diagnostic approaches in inherited diseases. But when it comes to variant curation, is AI capable of replacing human expertise? A new study by Stanford University compares data quality from their Automatic VAriant evidence DAtabase (AVADA) to the Human Gene Mutation Database (HGMD).

The results show that expert curation by variant scientists is irreplaceable in the field of clinical genomics, with HGMD recovering nearly 40% more disease-associated mutations than the AI-powered AVADA.

In this webinar, we demonstrate the depth and breadth of HGMD through a series of use-cases where the manually curated database outperforms AI solutions ..."

Webinar: Deploying SARS-CoV-2 wastewater monitoring in Kansas: A case study and adoption of high-throughput, automated sample processing

"The COVID-19 pandemic has highlighted the potential role that wastewater-based epidemiology (WBE) can play in assessing aggregate community health. However, efforts to translate SARS-CoV-2 gene copy numbers obtained from wastewater samples into meaningful community health indicators are nascent. This work will highlight two efforts to promote the use of WBE: 1) comparison of SARS-CoV-2 wastewater measurements during a low-frequency and a high-frequency clinical testing period and 2) adoption of automated, high-throughput methods to enable state-wide monitoring in Kansas."

Webinar: Navigate the technology landscape in predictive genomics: An introduction to key technology concepts and strategies

"Predictive genomics is a powerful capability to help predict disease risk and understand drug response in order to improve health outcomes and manage costs. This presentation will provide an overview of genome-wide sequencing and genotyping strategies for predictive genomics research. We will introduce three key whole-genome technologies: whole genome sequencing (WGS), low-pass sequencing (LPS) and genome-wide AxiomTM microarrays, and discuss how they can be integrated into technology strategies across various applications of predictive genomics research."

Webinar: Delivering Improved Bioprocessing Workflows: The Manufacturing Science and Technology (MSAT) Service

"Join us as we discuss the new Manufacturing Science and Technology (MSAT) Service offering, created in response to the needs of biopharmaceutical manufacturers for better cell culture media and buffer preparation methods. The MSAT Service focuses on developing user-friendly cell culture media for late-stage development and manufacturing of biologic drug substances and cell and gene therapies when priorities shift from process performance to improving efficiencies and reducing risks. Whether the needs are to reduce cost, save time, improve reliability, or all of the above, the MSAT Service helps identify opportunities for practical improvement of existing solution preparation processes. The MSAT service will provide support and targeted solutions to manufacturers, focusing on simplifying media preparation methods, improving the solubility of powder media, characterizing and troubleshooting the drug substance bill of materials, and introducing new technologies. Case studies will be provided as examples of targeted approaches toward simplifying complex media and buffer preparation methods to more user-friendly and robust methods."

Webinar: Lessons From The Laboratory: Optimizing Your Tissue Processing

"Have your research results or laboratory processes been bogged down by poor staining quality of histology slides? We all know that proper tissue processing is a key element to downstream staining quality, but do you know how to properly assess if your laboratory’s tissue processing is effective?

In this webinar, Senior Field Applications Specialist Robin Fitzl shares insights gleaned from her years of experience in the histology laboratories. Learn from Robin as provides insights via example of “what good looks like” in proper tissue processing, shares tips on what is “Optimal and Not”, and guide practitioners in obtaining high-quality staining results by optimizing tissue processing."

Webinar: Lean Lab – Testing Quality Attributes of Water for Pharmaceutical Production

"The quality of water for pharmaceutical production (purified water, water for injection, and ultrapure water) is quantified and regulated through four parameters – total organic carbon (TOC), conductivity, endotoxin, and bioburden. Historically, the testing of water for pharmaceutical production has been labor intensive and costly, requiring quality analysts to isolate samples from a water loop to evaluate the purity in the lab. These tests can take up to days to see results; therefore, pharmaceutical manufacturers either conditionally release water at risk of potential out-of-specification (OOS) results or delay production until results are reported. More recently, technologies have been developed to better support and streamline the release of water for production and improve the adoption of process analytical technologies (PAT) for greater efficiencies. Real-time release testing (RTRT) for TOC and conductivity, microfluidic technology for bacterial endotoxins testing (BET), and rapid microbiological methods (RMMs) for bioburden are all ways in which quality control laboratories can lean out processes and reduce human interference associated with water quality testing. Through the adoption of lean laboratory practices/PAT, pharmaceutical companies and their employees will benefit from improving process efficiencies, optimizing product release to market, ameliorating analysts’ workload, and maximizing sustainability all while maintaining data integrity and compliance."

Webinar: Techniques and Tips: Learn Sample Preparation for Next Generation Sequencing

Next Generation Sequencing (NGS) provides comprehensive genomic information about disease, development, and other biological processes. Though the NGS workflow has been vastly simplified, there are still technical aspects required for a successful experiment. Sample preparation remains a critical step for optimal results from NGS. This webinar provides information about: (1) techniques for nucleic acid extraction (2) instruments for nucleic acid extraction and their workflow (3) Tips and tricks for good quality sample extracts.

Webinar: Techniques and Tips: Learn Sample Preparation for Next Generation Sequencing

"Next Generation Sequencing (NGS) provides comprehensive genomic information about disease, development, and other biological processes. Though the NGS workflow has been vastly simplified, there are still technical aspects required for a successful experiment. Sample preparation remains a critical step for optimal results from NGS. This webinar provides information about: (1) techniques for nucleic acid extraction (2) instruments for nucleic acid extraction and their workflow (3) Tips and tricks for good quality sample extracts.

Learning Objectives
* Discover the sample prep workflow for FFPE, buccal swabs, and blood for nucleic acid extraction
* Discuss the do’s and don’ts of sample preparation for NGS
* Describe the tips and tricks for best nucleic acid quantification results"

Webinar: Top Tips for Achieving Compliance for Laboratory Balances

In this webinar, hosted by Sartorius, you will learn about data integrity and connectivity requirements for a modern laboratory balance. Register to find out how to be compliant with the latest guidelines for the pharmaceutical industry. Get to know how to achieve data integrity, minimize risk and the potential for FDA violations, and how digital workflows can be supported by technology like the Sartorius Cubis® II lab balance. In addition to that important news for the pharmaceutical industry will be highlighted. The new Chapter 2.1.7 of the European Pharmacopoeia will be compared with the United States Pharmacopeia Chapter 41, underlining the differences and discussing software solutions to ensure compliance with both chapters.

Webinar: Top Tips for Achieving Compliance for Laboratory Balances

"In this webinar, hosted by Sartorius, you will learn about data integrity and connectivity requirements for a modern laboratory balance. Register to find out how to be compliant with the latest guidelines for the pharmaceutical industry. Get to know how to achieve data integrity, minimize risk and the potential for FDA violations, and how digital workflows can be supported by technology like the Sartorius Cubis® II lab balance. In addition to that important news for the pharmaceutical industry will be highlighted. The new Chapter 2.1.7 of the European Pharmacopoeia will be compared with the United States Pharmacopeia Chapter 41, underlining the differences and discussing software solutions to ensure compliance with both chapters.

Learning Objectives
* Learn how you can ensure adherence to the updated European Pharmacopoeia guidelines
* Understand the differences between guidelines in Europe and the United States Pharmacopeia Chapter 41
* Learn how digital workflows can be supported by technology like the Sartorius Cubis® II lab balance"

Webinar: Lab Automation Solutions: How to move from time-consuming processes to efficient workflows

"The increased complexities of high-throughput workflows within the lab can increase demands on researchers. As your lab’s needs expand, automation may be the solution for time-consuming manual processes. From increased walk-away time and throughput, to reduced human error and improved lab safety, automation can keep routine work on track so that scientists can focus on more critical assay development challenges. Building an automation workcell for your lab can consist of different components, with each component offering its own advantage to the lab. In this webinar, we will provide information to highlight how automation can help researchers move from time-consuming processes to efficient workflows."

Webinar: Simplify the Development and Implementation of Diagnostic Testing in European Laboratories

"Many laboratories around the world have adopted expanded diagnostic testing capabilities to address the coronavirus pandemic and are now seeking ways to expand testing with additional workflows for infectious disease syndromic panels, pharmacogenomic analysis, oncology testing, and more.
Historically, developing a molecular test within a clinical laboratory has been perceived as a complicated and laborious process. In this webinar, we aim to dispel common misconceptions of in-house devices (IHD*) (also known as in-house test or in-house assay (IHA)) by providing a comprehensive overview of what it takes for a clinical laboratory to establish an in-house assay (IHA) in their laboratory."

Webinar: PFAS 101: What are they, where are they, how do we test for them?

"Per- and polyfluoroalkyl substances (PFAS) are manmade chemicals used in multiple industries - from paint to food packing - due to their surfactant and non-stick properties. In recent years PFAS have seen increasing attention from regulators as our understanding of their environmental persistence and biological impacts have evolved. And with regulations, come the need to accurately quantify PFAS, often at very low concentrations. Moreover, given the large family of known PFAS (>5,000), researchers and regulators are not only concerned with quantifying PFAS, but also with discovering as yet unknown PFAS.

PFAS 101: what are they, where are they, how do we test for them? is designed for people who want to learn about this increasingly important family of chemicals, including where we find them in our day-to-day lives and how to quantify/screen for them using LC-MS."

Webinar: Sample collection and concentration methods: Impact on wastewater-based surveillance for multi-pathogen panels

"Wastewater-based surveillance has gained wide recognition throughout the COVID-19 pandemic to monitor trends of SARS-CoV-2. While the current approaches focus on a single pathogen at a time, multi-pathogens surveillance is the future. Method to capture multi-pathogens in one go is not trivial. In our previous studies, we have found success recovering multi-pathogens from 6 liters of wastewater using the Bag Mediated Filtration System (BMFS) followed by skim milk flocculation. While this method performs well, it is costly and labor intensive. Therefore, we developed a new method using the Ceres Nanotrap® Microbiome A Particle, to capture pathogens from much smaller volumes of wastewater samples in Dhaka, Bangladesh. The Nanotrap particle method showed higher detection of SARS-CoV-2 (N1; 62.1%) than the BMFS method (38.2%). Additionally, the quality of the RNA from the Nanotrap particle method is more suitable for sequencing-based identification of SARS-CoV-2 variant of concern. However, the detection rate and recovery was higher using BMFS than Nanotrap particles for other pathogens, especially for enterovirus, norovirus, rotavirus, Shigella spp., and Salmonella Typhi. Working together with Ceres, we have also compared a new product, Nanotrap® Microbiome B Particles, to improve recovery of the other pathogens compared to BMFS. The combination of the two Nanotrap Particle types improved the detection of norovirus, Shigella spp., and Salmonella Typhi. However, the 6 liter BMFS method followed by skim milk flocculation still outperformed the results from the Nanotrap particle method for enterovirus and rotavirus. Overall, the Nanotrap process is more streamlined, requires significantly less wastewater, is less time-consuming, and is lower cost than BMFS. However, more research is needed to improve the ability to match the performance of BMFS for pathogens like enterovirus and rotavirus from wastewater."

Webinar: “From soup to nuts” – The journey of a sample through an automated clinical microbiology lab

"Ninety-eight percent of in-patients will undergo a diagnostic test during a hospital stay. With the increased focus on the accuracy of diagnostic test results needed to make informed decisions to treat outbreaks, antimicrobial resistance, and hospital acquired infections, optimizing your microbiology lab has never been more important. What does this look like? First, this means standardizing testing in the lab to produce consistent, timely quality results, and scaling the capacity of the lab to handle surges in patient specimen volumes. Next, it’s about accelerating turn-around time for specimen processing, so your lab can support the speed of diagnostic testing needed for clinicians to make the timely decisions required to manage their patients. During this webinar you will learn how automation, technology and change management can help improve your laboratory productivity KPIs and impact patient management."

Webinar: A Laboratory and Clinical Multi-disciplinary Partnership for the Treatment of Cancer Patients

"Adopting novel technologies is essential for improving patient outcomes, but the key to sustainable success is through strategic partnerships within the hospital. During this webinar, participants will learn the best practices for implementing innovative diagnostics, like T2 Biosystems sepsis panels, with first-hand experience from the University of Louisville Hospital through the lens of laboratory and clinical departments. Speakers will share their experiences collaboratively deciding on patient selection criteria, acting on diagnostic results, and educating clinicians on new technologies to meet operational and care-oriented goals. During the webinar, participants will learn the best practices for implementing innovative diagnostics, like T2Bacteria and T2Candida, with first-hand experience from the University of Louisville Hospital through the lens of laboratory and clinical departments."

Webinar: Avoiding Common Pitfalls in Laboratory Testing for Providers and Laboratorians

"In this case-based presentation, we will describe the most common pitfalls in laboratory testing that healthcare providers and clinical laboratory experts should be aware of, and how to mitigate their effects. Cases presented will cover problems that can arise in the pre-analytical, analytical and post-analytical phases of testing, including sample collection, transportation, and processing, effect of interferences on choice of analytical testing platforms, and the importance of using assay-specific pediatric reference intervals. Tests discussed will primarily include common chemistry tests like potassium, bicarbonate, creatinine, sodium, glucose and calcium and ALP. Attendees will be provided with practical ways to detect these issues (for providers), and how to reduce the likelihood of their occurrence (for laboratorians)."