LION bioscience Enters Cheminformatics Market with LeadNavigator
LION bioscience:
— LION Launches LeadNavigator(TM) for Lead Optimization and Prioritization
— LeadNavigator(TM) Offers Single Point of Access to Necessary Chemical Tools and Data
— Key Product Components Result of Successful Bayer Collaboration
LION bioscience announced the launch and immediate availability of LeadNavigator(TM), a chemically intelligent analytics product that enables research organizations to make faster and better compound identification, optimization and prioritization decisions. The new cheminformatics product allows researchers to analyze large sets of chemical and numerical data through a single, intuitive interface, which enables more efficient decision-making and collaboration by an organization without adding unnecessary complexity and overhead. LeadNavigator(TM) is a component of LION Lead Engine, LION’s cheminformatics product suite.
LeadNavigator(TM) leverages the technology developed by LION as part of the Bayer PIx (Pharmacophore Informatics) project. “The PIx project was initiated in 2000 to improve Bayer’s ability to identify, select and optimize the most promising drug candidates, by pulling together and visualizing data from several diverse sources. While regular chemical spreadsheets can partly solve this problem, the available solutions have not been well adapted for medicinal chemistry. Commercially available software has had limited chemical intelligence, forcing scientists to go back and forth between their data and their analysis tools, wasting valuable time,” said Hanno Wild, Ph.D., Head of Medicinal Chemistry at Bayer HealthCare AG. “The chemical worksheet is the central component of the PIx platform, and it is currently being used at Bayer by scientists worldwide. Through the chemical spreadsheet LION developed for us, Bayer scientists have access to all relevant data and tools from a single point of access. LION’s decision to productize this proven technology in LeadNavigator(TM) will be beneficial to the life science industry.”
“During the compound optimization stage of the discovery cycle, researchers are interested in not only figuring out the key structural features responsible for activity and selectivity, but also what structural changes need to be made to improve these characteristics,” said Joseph F. Donahue, LION’s Chief Business Officer and North American President. “In order to address these questions, a variety of search and analysis methodologies, along with visualization tools for structural and numerical data, are routinely deployed throughout an organization. As with biological data, chemical information is located in many different databases, with different interfaces, making it very frustrating to effectively use and make decisions from all of the available data. LeadNavigator(TM) provides easy access to all of these tools and data, through one interactive interface, which combines spreadsheet functionality and advanced data visualization capabilities with both standard statistical calculations and analyses methods specific to chemical compound selection.”
About LION LeadNavigator(TM)
LeadNavigator(TM) is a visually oriented, interactive desktop analytics product which helps researchers and research organizations make better decisions faster from the vast amounts of chemical and biological data generated in the life sciences research process. It includes a chemically intelligent spreadsheet that provides single point access to both standard statistical methods as well as algorithms used for compound identification, prioritization and optimization, including structure clustering, maximum common substructure calculation, R-group deconvolution, and Lipinski Rule value calculations that better assist research chemists in determining their compounds of interest. Synchronization between the spreadsheet and a range of linked graphical views, including scatter plots, histograms, and dendograms, help scientists find trends amongst the data. LeadNavigator(TM) can be integrated with an organization’s existing cheminformatics infrastructure, as well as be combined with leading commercial interfaces for accessing chemical and biological data, such as DeltaSoft’s ChemCart(TM) or the MDL(R) ISIS product suite. In addition, third party or in-house computational algorithms and tools can be integrated into the spreadsheet to provide additional functionality. LION LeadNavigator(TM) also includes a dataset of small molecule active compounds in FDA approved drugs, including prescription, over the counter, and discontinued chemical entities and their associated data derived from the FDA Orange Book, published by the U.S. Food & Drug Administration. Customers interested in updates to the FDA dataset can receive them from LION bioscience under a separate subscription agreement.
About LION bioscience
LION bioscience (ISIN: DE0005043509, Reuters: LIOG, Bloomberg: LIO, Nasdaq: LEON) provides proven information and knowledge management solutions to significantly improve life science R&D performance and productivity. Since it was founded in 1997, the company has become a recognized leader in the area of life sciences informatics. LION has operations worldwide in Heidelberg, Germany, Cambridge, UK and Cambridge, MA, USA LION’s products are distributed by CTC Systems in Japan and DigiGenomics in Taiwan.
LION’s (http://www.lionbioscience.com ) solutions are used by more than 27,000 researchers at over 300 academic and industrial customers globally. LION’s offerings include SRS for bioinformatics data access, LION Target Engine(TM) for target identification and validation, LION Lead Engine(TM) for lead identification and optimization, iDEA pkEXPRESS(TM) with analysis and prediction tools for ADME, and LION SolutionCenter(TM) professional services.
