Rosetta Biosoftware Introduces Version 5.0 of the Rosetta Resolver System; New Version Provides Flexible Data Analysis Environment

Rosetta Biosoftware introduced version 5.0 of the Rosetta Resolver(R) Gene Expression Data Analysis System today at its fourth annual user group meeting, ResolverTalk 2004. The Rosetta Resolver system, distributed exclusively by Agilent Technologies, is an enterprise solution for gene expression analysis used by leading life science organizations. Version 5.0 of the system provides a focus on meeting the specific expression analysis needs of users by providing enhanced:

— Customization — scientists have a broad choice of analysis options enabling fully customized processing and manipulation of data according to the specific needs of any user or research group. One of these features, R-integration, provides scientists with an easy to use non-programmatic environment to create, import, and use R scripts to perform data manipulations using their own algorithms or those in the public domain, such as Bioconductor.

— Biological Knowledge — version 5.0 of the Rosetta Resolver system provides scientists with enrichment tools for extracting biological meaning from expression data. Researchers use the Bioset Similarity Search feature to generate search results based on expression activities of Biosets, pathways or other gene sets.

— Productivity — enhancements included in the version 5.0 Resolver system will increase the overall productivity of research groups. Organizations engaged in collaborations will use the Gene Level Analysis feature to compare expression data generated from different microarray platforms such as the Affymetrix GeneChip and GE Healthcare Codelink arrays, thereby facilitating the sharing of results and knowledge about a research project.

“Rosetta Biosoftware aims to empower scientists to derive the most meaningful knowledge from their experiments using the methods that best fit their individual research goals,” said Yelena Shevelenko, general manager of Rosetta Biosoftware. “Through version 5.0 of the Rosetta Resolver system, we are furthering our commitment to meet scientists’ needs and provide them with the most powerful and flexible gene expression analysis solution.”

About the Rosetta Resolver System

The Rosetta Resolver system is a high-capacity data storage, retrieval and analysis solution for gene expression data. The system is ideal for life science research organizations that need to assess compound specificity or toxicity, identify new genes or therapeutic targets or compare and analyze large databases of expression profiles. The Rosetta Resolver system combines flexibility and ease of use with high-performance algorithms to produce an enterprise solution for rapid analysis of gene expression data. The Rosetta Resolver system can accept and analyze data from a wide variety of expression profiling formats, including Agilent DNA microarrays, and applies Rosetta Biosoftware’s proprietary error models to yield quality statistics for every gene expression measurement within the system. These statistics are automatically leveraged by Rosetta Resolver system analysis tools for optimal results. The system is also highly customizable, and includes a Software Development Kit (SDK) for extension and customization.

Life science research organizations that have licensed the Rosetta Resolver system include many of the top pharmaceutical companies in the world, such as Aventis Pharmaceuticals, Bristol-Myers Squibb, GlaxoSmithKline and Merck & Co., Inc., as well as premier academic institutions such as the Harvard University Center for Genomics Research. Additional information about the Rosetta Resolver system can be found on the Rosetta Biosoftware Web site at www.rosettabio.com .

About Rosetta Biosoftware

Rosetta Biosoftware is a leading provider of enterprise bioinformatics solutions for life science research. Its enterprise software solutions, including the Rosetta Resolver and Rosetta Luminator gene-expression data analysis systems, empower life scientists with advanced, scalable, and easy-to-use analysis platforms that accelerate discovery research. Rosetta Biosoftware is a business unit of Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc. (NYSE:MRK). More information about Rosetta Biosoftware is available at www.rosettabio.com .