Tripos Promotes Bryan Koontz to Senior Vice President and General Manager of Discovery Informatics

Tripos, Inc., a leading provider of drug discovery informatics products and chemistry research, announced it has promoted Bryan Koontz to senior vice president and general manager of Discovery Informatics. In his new role, Koontz will provide strategic direction for Tripos’ Discovery Informatics business, managing its offerings for both computational chemists and laboratory scientists, and will oversee the ongoing expansion of Tripos’ informatics portfolio.

Formerly chief executive officer of Optive Research, Inc., Koontz joined Tripos as vice president of marketing and corporate development when Tripos acquired Optive in January 2005. Koontz co-founded Optive, a discovery informatics software company, with professor Robert S. Pearlman as a technology spinoff from the University of Texas at Austin in 2002.

“Bryan is a dynamic, results-oriented leader with a clear and compelling vision for Tripos’ Discovery Informatics business. He has demonstrated acumen for business development, key alliance management and new product launches,” said Dr. John P. McAlister, president and chief executive officer of Tripos. “Furthermore, he has proven experience successfully leading a discovery informatics company, and has built many valuable relationships in our industry.”

Koontz holds a B.S. in mechanical engineering with a minor in engineering mechanics from The Pennsylvania State University and a M.S. in mechanical engineering from Massachusetts Institute of Technology.

He succeeds Dr. Trevor Heritage, who is leaving Tripos to pursue other interests.

About Tripos, Inc.

Tripos (Nasdaq:TRPS) combines leading-edge technology and innovative science to deliver consistently superior, chemistry-research products and services for the biotechnology, pharmaceutical and other life science industries. Tripos collaborates with clients to accelerate and improve the creation of life-enhancing products. Within Tripos’ Discovery Informatics (DI) business, the company provides software products and consulting services to develop, manage, analyze and share critical drug discovery information. Within Tripos’ Discovery Research (DR) business, Tripos’ medicinal chemists and research scientists partner directly with clients in their research initiatives, leveraging state-of-the-art information technologies and research facilities. Headquartered in St. Louis, Mo., Tripos spans the world with global research operations and an international client base. Further information on Tripos can be found at http://www.tripos.com .

Tripos and the Tripos logo are registered trademarks of Tripos, Inc., and/or its affiliates in the United States and certain other countries. All other trademarks mentioned in this document are the property of their respective owners.