Tripos Streamlines High-Throughput Screening Data Analysis With Release Of SARNavigator 1.5
Tripos, Inc. (Nasdaq:TRPS), a leading provider of drug discovery informatics products and chemistry research, today announced the release of SARNavigator™ 1.5, a new research application that allows scientists to rapidly and objectively analyze the large quantities of chemical and biological data that comprise the results of real or virtual high-throughput screening. Using SARNavigator 1.5, researchers can rapidly identify and distinguish biologically active chemical series from the wealth of data contained in screening results, then effectively prioritize those series for further research, reducing traditional screening analysis timelines from weeks or months to hours or days.
“SARNavigator was collaboratively developed between Tripos and HTS data analysis groups at several major pharmaceutical companies,” said Dr. David Lowis, senior director of discovery software at Tripos. “It has been successfully deployed at a number of companies to identify high-quality chemical series from high-throughput screening experiments for use in secondary screening and further chemical exploration.”
The new SARNavigator 1.5 release consists of three components:
- SARNavigatorBASE™, a high-capacity chemical spreadsheet with substructure searching and chemical management capabilities, including descriptor calculation and analysis tools that include structure-activity relationships (SAR) table generation
- SARNavigatorHQSAR™, a rapid, automated quantitative structure-activity relationships (QSAR) technique for creating predictive models and prioritizing chemical series from high-throughput data analysis
- SARNavigatorHTS™, a complete tool set for the analysis of high-throughput screening (HTS) and virtual high-throughput screening data through novel and patented datamining algorithms (SAR Rules), and for visualization and exploration of entire SAR landscapes (SAR Maps), including definition, management and prioritization of chemical series
SARNavigator’s SAR Maps enable users to visualize all biologically relevant chemical information from a high-throughput screen, while SAR Rules provide an automated method to locate likely chemical series based on shared substructures. Combined, SAR Maps and SAR Rules allow researchers to simultaneously navigate multidimensional molecular similarity spaces to locate the most promising series of compounds. This objective and versatile process enhances the success rate of downstream research by ensuring the best possible decisions are made at the earliest stage of chemical research.
About Tripos, Inc.
Tripos (Nasdaq:TRPS) combines leading-edge technology and innovative science to deliver consistently superior chemistry-research products and services for the biotechnology, pharmaceutical and other life science industries. Tripos collaborates with clients to accelerate and improve the creation of life-enhancing products. Within Tripos’ Discovery Informatics (DI) business, the company provides software products and consulting services to develop, manage, analyze and share critical drug discovery information. Within Tripos’ Discovery Research (DR) business, Tripos’ medicinal chemists and research scientists partner directly with clients in their research initiatives, leveraging state-of-the-art information technologies and research facilities. Headquartered in St. Louis, Mo., Tripos spans the world with global research operations and an international client base. Further information on Tripos can be found at http://www.tripos.com .
