Waters Corporation and Nonlinear Dynamics Form Life Science Partnership
Waters Corporation and Nonlinear Dynamics Limited of Newcastle upon Tyne, UK will announce a far reaching co-development and co-marketing partnership at the Human Proteome Organization (HUPO) World Congress, Munich, Germany, August 28 – September 1. Waters and Nonlinear Dynamics will co-develop and co-market integrated bioinformatics solutions for protein identification and quantitative protein profiling that will leverage Waters UPLC™ chromatography products and exact mass MS data acquisition systems for proteomics research. Financial terms of the partnership were not disclosed.
Initially Waters ProteinLynx Global Server™ 2.2.5 protein mass-informatics system and Nonlinear Dynamics Progenesis™ 2006 2D Gel-informatics platform will be configured for seamless interoperability enabling gel image analysis data and confident protein identifications by either MALDI-MS/MS or ESI-MS/MS to be integrated. Life scientists will benefit from the ability to view 2D gel images with full protein identity annotation within either informatics platform. Going forward the partners will co-develop multivariate approaches to biomarker discovery and orthogonal label-free protein quantification strategies.
Nonlinear Dynamics’ comprehensive portfolio of bioinformatics software and experience in specialist software development for life science research uniquely complements Waters advanced UPLC™ products for nano-scale applications and exact mass MS/MS technologies for protein identification and quantitative/qualitative protein profiling.
Waters® Protein Identification System
Waters Protein Identification System features the Micromass ® MALDI micro MX™ analyzer, a unique matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS and MS/MS). The MALDI micro MX offers the simplest route to higher quality MS/MS data by MALDI mass spectrometry with a novel multiplexed Post-Source Decay (‘PSD MX’) capability. The system rapidly confirms the identity of proteins excised from 2D gels and reveals post-translational modifications with high confidence.
Waters Protein Expression System for Quantitative/Qualitative Profiling
The Waters Protein Expression System is the industry’s first label-free system to give scientists the ability to quantitatively assess changes in protein expression while performing enhanced qualitative protein identification – all within the same LC/MS run. The unique system uses a patented implementation of exact mass measurement and LC/MS with parallel collision induced dissociation (MS E) of tryptic peptide precursor ions to yield a Global Expression Dataset of a complex protein digests mixture. Global Expression Datasets can then be exhaustively mined post-acquisition for quantitative/qualitative features (e.g. biomarkers) with Waters proprietary Expression Informatics tools.
About Nonlinear Dynamics Limited ( www.nonlinear.com )
Established in 1989, Nonlinear Dynamics is a leading worldwide provider of bioinformatics solutions to the life science industry. The company’s innovative product portfolio comprises high-quality analysis and data mining tools for single dimension and 2D electrophoresis gels and microarrays, the core technologies of genomics and proteomics. Nonlinear sells and supports its products through its UK headquarters, its USA office, and its global network of partners and OEMs.
About Waters Corporation ( www.waters.com )
Waters Corporation holds worldwide leading positions in three complementary analytical technologies: liquid chromatography, mass spectrometry, and thermal analysis. These market segments account for $4.5 – $5.0 billion of the overall $20+ billion analytical instrumentation market.
Waters is dedicated to leveraging life science research from biomarker discovery through advanced therapy development to the facilitation of novel molecular diagnostics. Waters, Micromass, Ultra Performance LC, MALDI micro MX, and ProteinLynx Global Server are trademarks of Waters Corporation. Progenesis is a trademark of Nonlinear Dynamics.
