Development and validation of a fast gas chromatography–mass spectrometry method for the determination of cannabinoids in Cannabis sativa L

In this 2018 paper published in the Journal of Food and Drug Analysis, Cardenia et al. discuss their development of a “routine method for determining cannabinoids” in the flowers of Cannabis sativa L. using fast gas chromatography coupled to mass spectrometry (fast GC-MS), with appropriate derivatization approaches that take into account potential decarboxylation. The authors discuss the various problems with other methods then present their materials and methods. After considerable discussion of their results, they conclude that the procedure is fast (within seven minutes), has good resolution (R > 1.1), and remains cost-effective. Sensitivity was also high, with “a high repeatability and robustness in both cannabinoid standard mixtures and hemp inflorescence samples.”

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