Metabolomic analysis of cannabinoid and essential oil profiles in different hemp (Cannabis sativa L.) phenotypes

Noting a dearth of published research on "cannabinoid and terpenoid profiles in different hemp phenotypes within the same variety," Eržen et al. of the Slovenian Institute of Hop Research and Brewing and the University of Ljubljana took matters into their own hands and conducted such a study. The researchers examined 11 phenotypes from three different Cannabis varieties: Carmagnola Selected (CS), Tiborszallasi (TS), and Finola Selection (FS). Their objective? They intended "to establish a connection between the chemical composition and morphological characteristics of hemp plants and to identify phenotypes with an interesting ratio between cannabinoids for further pharmaceutical applications." After providing background and reasoning for selecting their varieties, the authors discuss the results of their chemical analyses as well as the materials and methods they used. The authors conclude by summarizing their findings, including specific phenotypes that could be prime targets for further cannabis pharmaceutical research.

Development and implementation of an LIS-based validation system for autoverification toward zero defects in the automated reporting of laboratory test results

In this 2021 paper published in BMC Medical Informatics and Decision Making, Jin et al. discuss an autoverification and validation system they implemented in their laboratory information systems (LIS) to decrease validation workloads and reduce reporting risks in their healthcare systems. Using a human-machine dialog approach, the authors developed and implemented their autoverification system so that it could record personnel review steps and determine whether the human–machine review results are consistent, while also allowing laboratory personnel to tweak the system further for improved autoverification accuracy. After describing their system in detail, the authors present the results of their two years of use with the system, noting that "in the two years that our online validation has been in use, there have never been any defects or reporting risks due to autoverification" while at the same time enjoying more efficient laboratory verification.

Emerging and established trends to support secure health information exchange

In this 2021 article published in Frontiers in Digital Health, Spanakis et al. describe their research efforts towards the development of a more advanced way of securely transmitting and sharing sensitive healthcare data, including by use of blockchain and cloud computing. They first provide background on interoperability and data sharing in healthcare and the challenges that face such activities. This background also includes discussion of an interoperability framework in the European context and how it could be applied to their research. The authors then discuss the current status of standards-based health data exchange and how blockchain fits into that picture. They then propose their Innovative Secure Information Sharing Platform (InSISP), which is "able to support a fast and efficient medical information sharing at both national and cross-national levels, taking into account sharing constraints, including those imposed by the General Data Protection Regulation (GDPR)." Afterwards, they summarize their recommendations based on their InSISP, concluding that their platform has the potential improve healthcare data sharing and transmission, though not without challenges in addressing blockchained healthcare data in the scope of GDPR, as well as the overall complexity and heterogeneity of big healthcare data and the problems that arise.

Security and privacy in cloud-based eHealth systems

Electronic health or eHealth solutions are increasingly used in healthcare, including in cloud computing settings. The cloud adds benefits to the use of those eHealth systems, but it also brings with it a number of security challenges, as Sivan and Zukarnain highlight in this 2021 paper. The duo turn to a literature review of eHealth technologies in relation to cloud computing and use that literature to show the strengths and weaknesses of a cloud-based eHealth systems approach. After providing background on cloud computing and the advantages it brings to eHealth systems, the authors identify security issues introduced by moving to the cloud and what security methods can help resolve those issues. They close with a recap of the proposed solutions, future directions for cloud-based eHealth security, and the conclusion that "the future of cloud-based eHealth services will be the integration of file-based and cloud-based applications that integrate a computer-based hybrid IT solution that measures the flexibility and scalability associated with cloud management and healthcare data security."

Using interactive digital notebooks for bioscience and informatics education

In this 2020 paper published in PLOS Computational Biology, Davies et al. of the University of Manchester discuss their experiences implementing Jupyter Notebooks in bioinformatics and health informatics education. Through these digital notebooks, the researchers were able to help teach future laboratorians with little coding experience how to perform basic coding of health informatics applications, as well as more advanced postgraduates how to apply the notebook to bioinformatics activities. After discussing the inner working of the Jupyter Notebook, the authors explain how such notebooks are able to enhance collaboration and reproducibility in laboratories, as well as improve learning and student assessment in the classroom. They then describe two education-based case studies of using the notebooks, and they describe the end results. The authors conclude that, given their experience as well as their students' experience, such notebooks can act "as a useful resource for learning to code and communicate research findings and analysis" in higher education, with the experience being transferrable to professional work in the future.

The Application of Informatics to Scientific Work: Laboratory Informatics for Newbies

Informatics expert Joe Liscouski is back with another short laboratory informatics guide, this time geared towards those who are relatively new to the concept. In this 2021 guide, Liscouski approaches the various concepts surrounding laboratory informatics, but by first addressing the laboratory itself. What types of scientific and laboratory work are conducted? What's the difference between a research laboratory and a testing or "service" laboratory? How are the workflows different between the two? Liscouski notes that documenting data is critical to both types of laboratories, and historically, the paper-based laboratory notebook has been that tool. From there, he makes the logical leap to electronically documenting the same data, first by word processor and then by the electronic laboratory notebook (ELN). From there, integrating these electronic variations is addressed, as well as how other informatics tools like a laboratory information management system (LIMS) and scientific data management system (SDMS) shape and fit into laboratory workflows. He concludes by discussing the actual planning necessary for implementing these and other laboratory informatics solutions in the lab.

Blockchain-based healthcare workflow for IoT-connected laboratories in federated hospital clouds

What do the internet of things (IoT), cloud computing, and blockchain all bring to the table of healthcare, particularly during a pandemic? Celesti et al. demonstrate in this 2020 article published in Sensors that the considerate combination of these technologies can lead to a "scenario where nurses, technicians, and medical doctors belonging to different hospitals cooperate through their federated hospital clouds to form a virtual health team able to carry out a healthcare workflow in secure fashion." The authors show how an IoT-connected laboratory that feeds its instrument data into a federated hospital cloud integrated with a blockchain engine can lead to less patient movement and better security of patient data, while also allowing nurses, doctors, and other practitioners from any of the connected hospitals to review results and issue treatments from a distance. They show the results of several experiments with such a system and conclude by promoting its benefits, as well as the possibility of extending the system to the pharmacy world.

Informatics-driven quality improvement in the modern histology lab

In this brief 2020 paper published in JAMIA Open, Seifert et al. of the University of Florida health system share their experiences with taking their Beaker LIS implementation and improving its data tracking capabilities, which in turn improved "trainee education, slide logistics, staffing and instrumentation lobbying, and task tracking" within their anatomic pathology laboratories. After a brief introduction, the authors demonstrate Beaker's status board and weaknesses, and then show how they used Beaker's MyReports module to develop an improved status board. They then state six significant challenges and how they used the adapted LIS tools to solve them. They conclude that "the technical and/or functionality framework that we demonstrated in this manuscript could be adapted by other institutions to address common problems encountered by anatomic pathology laboratories."

Accelerated solvent extraction of terpenes in cannabis coupled with various injection techniques for GC-MS analysis

In this 2021 paper published in Frontiers in Chemistry, Myers et al. of Restek and Verity Analytics provide details of their research on better terpene analysis methods in Cannabis plant materials. The research focused on " the more traditional headspace syringe (HS syringe) and liquid injection syringe (LI syringe) approaches" compared to two more modern approaches to terpene analysis: HS-solid-phase microextraction Arrow (HS-SPME Arrow) and DI-SPME Arrow. After describing their experiments and results, the authors made multiple conclusions. First, they found "that DI-SPME Arrow performed better than HS-SPME Arrow; however, both of these approaches outperformed HS syringe for the extraction and analyses of terpenes." However, their results that LI syringe proved best, though not without some considerations concerning instrument uptime, compared to other methods. They also make a number of recommendations to cannabis laboratories and scientific researchers based upon their findings in order to "improve the science of cannabis testing."

Popularity and performance of bioinformatics software: The case of gene set analysis

In this 2021 paper published in BMC Bioinformatics, Xie et al. examine big omics and gene set analysis, a common analytical technique for bioinformaticists. The authors argue that biomedical science researchers have not been using the best GSA methods among those that are actually available. They chose to conduct research of popularity and performance based on prior described validation strategies and existing benchmark studies. Noting that popular methods are not always the best methods, the authors conclude with five points from their research, including a need for deeper discussions and research about GSA methods and more rigorous validation procedures for GSA tools. They also provide examples of evaluational tools for GSA and other bioinformatics software.

Privacy-preserving healthcare informatics: A review

Last week's article looked at inference attacks in the cloud, but they happen in other ways as well. In this 2021 paper, Chong reviews the available literature on inference and other privacy attacks that occur on published healthcare information originally sourced from electronic health records (EHRs) and other health informatics systems. Ethical sharing of this kind of data with researchers conducting statistical analysis, improving clinical decision making, etc. is important, but it must preserve the privacy of the underlying individuals. After briefly discussing data publishing with a strong privacy focus, Chong looks at how healthcare data is typically stored and what threats exist against such data. The author then examines two well-established privacy models, including their strengths and limitations, that can be used to limit those threats: data anonymization and differential privacy. Despite these models, Chong closes by noting that "preserving privacy in healthcare data still poses several unsolved privacy and utility challenges" and expounds on areas for future research into those challenges.

Secure data outsourcing in presence of the inference problem: Issues and directions

Inference attacks occur when a (typically) malicious actor is able to infer from public information more sensitive information about a database or individual without directly accessing the original database or sensitive user information. That these sorts of attacks can be successful against applications and data on cloud-based infrastructure should not be a surprise to seasoned IT veterans. Recognizing these concerns, Jebali et al. examine the state of inference attacks in the cloud, the research that has been conducted so far on such attacks, and what can be done about them. Aside from examining a variety of security concerns in both communicating and non-communicating servers, the authors also address the inference problem, offering a potential solution that will in theory "optimize data distribution without the need to query the workload, then partition the database in the cloud by taking into consideration access control policies and data utility, before finally running a query evaluation model on a big data framework to securely process distributed queries while retaining access control." They conclude by recognizing more research must be done to test their proposed solution, and noting that past research has often overlooked other types of inference sources such as inclusion dependencies, join dependencies, and multivalued dependencies, which should be further examined.

Digital transformation risk management in forensic science laboratories

In this 2020 paper published in Forensic Science International, Casey and Souvignet present their ideas on how forensic laboratories with significant digital footprints should best prepare their operations to ensure their processes and digital data can be independently verified. Their recommendations come as they recognize how "digital transformations can undermine the core principles and processes of forensic laboratories" when those transformations are not planned and implemented well, risking the lab's integrity as well as the fundamental rights of individuals being forensically examined. After a brief introduction, the authors then present five risk scenarios and four technological improvement scenarios, followed by a discussion of a series of risk management practices to ensure digital transformations in the forensic laboratory are optimized and effective. They finally touch upon the value of in-house expertise and quality assurance practices in the lab, before concluding that "with proper forethought and preparation, forensic laboratories can employ technology and advanced data analytics to enhance existing services and create new services, while respecting fundamental human rights."

Named data networking for genomics data management and integrated workflows

Managing and sharing big data in the cloud has its own set of cyberinfrastructure challenges, and that includes genomic research data. With large data sets being stored in numerous geographically distributed repositories around the world, effectively using this data for research can become enormously difficult. As such, Ogle et al., writing in Frontiers in Big Data, present their efforts towards reducing these network challenges using an internet architecture called named data networking (NDN). After discussing NDN, the authors describe the problems that come from wanting to manage and use big genomic data sets, as well as how NDN-based solutions can alleviate those problems. They then describe their method towards implementing NDN with genomics workflow tool GEMmaker in a cloud computing platform called the Pacific Research Platform. Through their efforts, they conclude that "NDN can serve data from anywhere, simplifying data management," and when integrated with GEMmaker, "in-network caching can speed up data retrieval and insertion into the workflow by six times," further improving use of big genomic data in practical research.

Implement an international interoperable PHR by FHIR: A Taiwan innovative application

In this 2020 paper published in the journal Sustainability, Lee et al. provide details on their FHIR-based personal health record (PHR) system in Taiwan, which arguably has one of the best health systems in the world. With the Taiwan National Health Insurance Administration wanting to give its citizens more control over the health data, the demand has been there to improve how the average person can take a more proactive stance with their medical treatment. After reviewing relevant literature, the authors describe the evolution of their PHR platform, including content analysis, data conversion, networking, authentication, and security. Then, based upon their results, they conclude that the process of taking PHR data and applying international standards to its organization and presentation, they were able to effectively "achieve interoperability as well as capture and share data using FHIR resources and formats" while maintaining a sturdy but flexible user authentication mechanism.

Towards a risk catalog for data management plans

A data management plan (DMP) is a formally developed document that describes how data shall be handled both during research efforts and afterwards. However, as Weng and Thoben point out in this 2020 paper, "it a problem that DMPs [typically] do not include a structured approach for the identification or mitigation of risks" to that research data. The authors develop and propose a generic risk catalog for researchers to use in the development of their DMP, while demonstrating that catalog's value. After providing and introduction and related work, they present their catalog, developed from interviews with researchers across multiple disciplines. They then compare that catalog to 13 DMPs published in the journal RIO. They conclude that their approach is "useful for identifying general risks in DMPs" and that it may also be useful to research "funders, since it makes it possible for them to evaluate basic investment risks of proposed projects."

Accounting and the US cannabis industry: Federal financial regulations and the perspectives of certified public accountants and cannabis businesses owners

Cannabis-related businesses (CRBs) in U.S. states where cannabis is legal have long had difficulties finding the banking and financial services they require in a market where the federal government continues to consider cannabis illegal. Working in cash-only situations while trying to keep careful accounting, all while trying to keep the business afloat and clear of legal troubles, remains a challenge. This late 2020 paper by Owens-Ott recognizes that challenge and examines it further, delving into the world of the certified public accountant (CPA) and the role—or lack thereof—they are willing to play working with CRBs. The author conducted a qualitative study asking 1. why some CPAs are unwilling to provide services to CRBs, 2. how CRBs compensate for the lack of those services, and 3. what CPAs need to know in order to provide effective services to CRBs. Owens-Ott concludes that "competent and knowledgeable CPAs" willing to work with CRBs are out there, but the CPAs should be carefully vetted. And interested CPAs "must commit to acquiring and maintaining substantial specialized knowledge related to Tax Code Section 280E, internal controls for a cash-only or cash-intensive business, and the workings of the cannabis industry under the current regulatory conditions."

Kadi4Mat: A research data infrastructure for materials science

This 2021 paper published in Data Science Journal explains Kadi4Mat, a combination electronic laboratory notebook (ELN) and data repository for better managing research and analyses in materials sciences. Noting the difficulty of extracting and using data obtained from experiments and simulations in the materials sciences, as well as the increasing levels of complexity in those experiments and simulations, Brandt et al. sought to develop a comprehensive informatics solution capable of handling structured data storage and exchange in combination with documented and reproducible data analysis and visualization. Noting a wealth of open-source components for such an informatics project, the team provides a conceptual overview of the system and then dig into the details of its development using various open-source components. They then provide screenshots of records and data (and metadata) management, as well as workflow management. The authors conclude their solution helps manage "heterogeneous use cases of materials science disciplines," while being extensible enough to extend "the research data infrastructure to other disciplines" in the future.

Laboratory Technology Planning and Management: The Practice of Laboratory Systems Engineering

This guide by laboratory automation veteran Joe Liscouski takes an updated look at the state of implementing laboratory automation, with a strong emphasis on the importance of planning and management as early as possible. It also addresses the need for laboratory systems engineers (LSEs)—an update from laboratory automation engineers (LAEs)—and the institutional push required to develop educational opportunities for those LSEs. After looking at labs then and now, the author examines the transition to more automated labs, followed by seven detailed goals required for planning and managing that transition. He then closes by discussing LSEs and their education, concluding finally that "laboratory technology challenges can be addressed through planning activities using a series of goals," and that the lab of the future will implement those goals as early as possible, with the help of well-qualified LSEs fluent in both laboratory science and IT.

Considerations in the Automation of Laboratory Procedures

This white paper by laboratory automation veteran Joe Liscouski examines what it takes to fully realize a fully integrated laboratory informatics infrastructure, a strong pivot for many labs. He begins by discussing the worries and concerns of stakeholders about automation job losses, how AI and machine learning can play a role, and what equipment may be used, He then goes into lengthy discussion about how to specifically plan for automation, and at what level (no, partial, or full automation), as well as what it might cost. The author wraps up with a brief look at the steps required for actual project management. The conclusion? "Just as the manufacturing industries transitioned from cottage industries to production lines and then to integrated production-information systems, the execution of laboratory science has to tread a similar path if the demands for laboratory results are going to be met in a financially responsible manner." This makes "laboratory automation engineering" and planning a critical component of laboratories from the start.
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