Development of standard operating protocols for the optimization of Cannabis-based formulations for medical purposes

In this 2019 paper by Baratta et al., published in Frontiers in Pharmacology, the authors examine a variety of different procedures for preparing decoctions and oil-based extracts using the Cannabis plant. Using the different formulations as a base, they wanted to determine the efficacy of the various "standard operating procedures for the preparation and optimization of Cannabis-based galenic formulations." After discussing the materials and methods, and reviewing the results, the authors discussed the ramifications of their research, in particular in contrast to what the Italian government recommends procedure-wise. They concluded that their "β-4" method of oil preparation yielded "significantly higher [recovered THC and CBD] compared to those with water-based extraction (decoctions) or other current oil-based extraction techniques."

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