Quality control of cannabis inflorescence and oil products: Response factors for the cost-efficient determination of ten cannabinoids by HPLC

In this 2022 paper published in Talanta Open, Hall et al. propose an analytical method for 10 cannabis-related cannabinoids that is cost-efficient, rapid, and robust in its use. Noting “elevated cost and limited availability of certified analytical reference standards for some cannabinoids,” the authors sought to develop a high-performance liquid chromatography-photodiode array (HPLC-PDA) method for 10 cannabinoids that uses “relative retention times (RRT) for peak identification and relative response factors (RRF) for their quantification.” After describing their materials and methods, the authors present their results and discuss their implications towards various aspects such as accuracy, recovery, and quantification. They conclude that their method is robust, acceptably accurate, and has sufficient dynamic range. They add that with their method, “cost barriers for the analysis of panels of cannabinoids can be overcome, such that a diversity of cannabinoids can be analyzed as a part of routine quality control, with results that reflect the therapeutic efficacy for the consumer.”

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