Simultaneous quantification of 17 cannabinoids in cannabis inflorescence by liquid chromatography–mass spectrometry

In this 2022 paper published in Separations, Hewavitharana et al. examine a more simplified means of quantifying cannabinoids using liquid chromatography–mass spectrometry (LC-MS) with a low flow rate rather than a more expensive ultra-high-performance liquid chromatography (UHPLC) system. After descrribing their materials and methods used, the authors discuss the optimization of their extraction method, as well as the optimization of chromatographic separation and mass spectrometry, and how the processes were validated. They conclude that “the main advantage of using this approach is that the method can be easily adapted to use with a simple HPLC-MS (single quadrupole) system,” and that “the method is well suited for routine phytocannabinoid analysis across a range of applications in a variety of laboratory settings.”

Please to read the entire article.