SeqWare Query Engine: Storing and searching sequence data in the cloud

In 2010, O’Connor et al. published a paper on their experience developing and implementing a cloud-based query engine that can support thousands of genome datasets. Still actively developed as of 2015, the SeqWare Query Engine “can load and query variants (SNVs, indels, translocations, etc) with a rich level of annotations including coverage and functional consequences.” The research team concluded in their paper that the software was then “capable of supporting large scale genome sequencing research projects involving hundreds to thousands of genomes as well as future large scale clinical deployments utilizing advanced sequencer technology that will soon involve tens to hundreds of thousands of genomes.”

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