Chemical profiling and characterization of different cultivars of Cannabis sativa L. inflorescences by SPME-GC-MS and UPLC-MS

In this 2022 journal article published in Separations, Cicaloni et al. present their finding from applying advanced analysis techniques and statistical survey methods to five different Cannabis sativa cultivars grown in Italy. After providing an introduction on the chemical characteristics of cannabis, the authors describe their materials and methods used, including solid-phase microextraction and ultra-performance liquid chromatography–mass spectrometry, as well as statistical methods such as partial least squares discriminant analysis (PLS-DA) and heat mapping with principal component analysis (PCA). After thoroughly presenting their results, the authors discuss their findings, concluding that given the vital importance of understanding the chemical composition of cannabis “for the development of new products for pharmaceutical, medical, and other uses,” their results should “provide more information on C. sativa inflorescences from five different cultivars, which may be useful for further investigations of metabolite applications in scientific research.”

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