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Masashi Yanagisawa (柳沢 正史, Yanagisawa Masashi, born May 25, 1960) is a Japanese-American molecular biologist and physician, famous for his discovery of the hormone endothelin and the neuropeptide orexin, the absence of which is the cause of narcolepsy. He is currently the Director of the International Institute for Integrative Sleep Medicine, University of Tsukuba, and an adjunct professor at the Department of Molecular Genetics, University of Texas Southwestern Medical Center.[3]
Masashi Yanagisawa | |
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柳沢 正史 | |
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Born | [2] Tokyo, Japan | May 25, 1960
Nationality | American |
Citizenship | United States |
Education | University of Tsukuba (MD, PhD) |
Awards | Kilby International Awards Bristol-Myers Squibb Award for Distinguished Achievement in Cardiovascular Research Medal of Honor with Purple Ribbon Asahi Prize Keio Medical Science Prize Person of Cultural Merit Breakthrough Prize in Life Sciences |
Scientific career | |
Fields | Molecular biology |
Institutions | Kyoto University University of Texas Southwestern Medical Center Howard Hughes Medical Institute University of Tsukuba |
Thesis | A novel potent vasoconstrictor peptide produced by vascular endothelial cells (1988) |
Doctoral advisor | Tomoh Masaki[1] |
Early life and education
Yanagisawa was born in Tokyo in 1960. His father was a surgeon and, thanks to his background in electrical and electronic engineering, an electrophysiology researcher.[4] He graduated from Musashi Junior and Senior High School in 1979, and entered the University of Tsukuba to study medicine. After obtaining an MD in 1985, he pursued a PhD at the same institute, completing it 3 years later.[3]
Career
Immediately after obtaining his PhD, Yanagisawa started his career as a postdoctoral fellow at the Department of Pharmacology of the University of Tsukuba.[3] One year later, he became an assistant professor at the same department, and in 1991 moved to the Kyoto University School of Medicine as an assistant professor at the Department of Pharmacology.[5]
Yanagisawa stayed at Kyoto only for one year, after which Joseph L. Goldstein and Michael Stuart Brown, both 1985 Nobel Prize in Physiology or Medicine laureates and famous for their research in cholesterol, recruited him to the University of Texas Southwestern Medical Center (UTSW).[1] He began as an associate professor at the Department of Molecular genetics,[6] was promoted to full professor in 1996,[5] and endowed with the Patrick E. Haggerty Distinguished Chair in Basic Biomedical Science in 1998.[2]
Between 2001 and 2006, he had his own project under the Japan Science and Technology Agency ERATO (Exploratory Research for Advanced Technology) scheme, focusing on discovering endogenous ligands for orphan receptors.[7]
He returned to Japan in 2012 to found and direct the International Institute for Integrative Sleep Medicine at the University of Tsukuba, which was established under the World Premier International Research Center Initiative by Japan's Ministry of Education, Culture, Sports, Science and Technology.[8] Two years later, he switched to part-time at UTSW as an adjunct professor.[5] Yanagisawa was also an investigator at the Howard Hughes Medical Institute during his time working full-time at UTSW.[9]
Research
Yanagisawa is most well known for his discovery of the hormone endothelin and the neuropeptide orexin. Early 1980s saw the revelation that nitric oxide was the substance endothelial cells produce to relax the smooth muscle around blood vessels, which causes vasodilation and increased blood flow.[10] This led to the speculation of and hunt for the inverse, an endothelium-derived vasoconstricting substance.[11] During his PhD study, Yanagisawa's supervisor, Tomoh Masaki, agreed to let him try to isolate the substance. This study became his PhD thesis, and he published his finding it 1988, naming the substance "endothelin" and reporting its peptide sequence.[12] He then published a number of reports on the function and regulation of endothelin, including working with Takeshi Sakurai to identify the receptor for endothelin.[13]
He kept studying endothelin after moving to the University of Texas Southwestern Medical Center (UTSW) in the United States, for example discovering one of the mechanisms to activate endothelin[14] and that a mutation in endothelin receptor can cause Hirschsprung's disease.[15]
Eventually, his interest in endothelin diminished and Yanagisawa switched his focus to orphan receptors, which are receptors whose endogenous ligands have yet to be identified, particularly orphan G protein-coupled receptors (GPCRs). In 1998, again teaming up with Takeshi Sakurai, who has moved to the United States as a postdoctoral fellow at UTSW, Yanagisawa connected two orphan GPCRs with a family of neuropeptides as their ligands. They named it "orexin" after the Greek word for appetite, since the neuropeptide was found exclusively in the hypothalamus, a brain region that regulates appetite, and because mice consumed more food after receiving a dose of orexin.[16] Another group at The Scripps Research Institute (now Scripps Research) made the same discovery in the same year, and named the neuropeptide "hypocretin".[17] Today, "hypocretin" (or HCRT) is used to refer to the gene and transcript, while "orexin" is used to refer to the peptide.[18]
Yanagisawa and his team then knocked out the orexin gene in mice, hoping to see the animal eating less. Instead, they observed behavior similar to the human condition of narcolepsy, whose cause at the time was still unknown.[19] The association between orexin and narcolepsy was definitively established not long afterwards in 2000.[20]
Since then, his research has mostly focused on studying sleep and orphan receptors. For example, he uncovered the functions of GPR7 (NPBW1) and GPR8 (NPBW2),[21] GPR41 (FFA3),[22] and GPR103 (QRFPR).[23]
More recently, using an unbiased forward genetics approach, which randomly introduced mutations in mice and then observed their electrocardiogram and electromyogram, Yanagisawa and his team reported the role of KIAA0999 (encoded by the Sik3 gene) and NALCN (encoded by the Nalcn gene) in regulating sleep.[24][25] His team also identified the phosphorylation and dephosphorylation of 80 proteins as a major regulation mechanism of the sleep cycle in mice.[26]
Honors and awards
- Kilby International Awards (1998)[27]
- Robert J. and Claire Pasarow Foundation Award in Cardiovascular Medical Research (1997)[28]
- Novartis Award For Hypertension Research, American Heart Association (1998)[29]
- John J. Abel Award in Pharmacology, American Society for Pharmacology and Experimental Therapeutics (1998)[30]
- Amgen Award, American Society of Biochemistry and Molecular Biology (1999)[24]
- Jacobæus Prize, Novo Nordisk Foundation (2001)[31]
- Bristol-Myers Squibb Award for Distinguished Achievement in Cardiovascular Research (2003)[32]
- Member of the National Academy of Sciences (2003)[33]
- Ulf von Euler lecture, Karolinska Institute (2012)[34]
- Walter B. Cannon Award Lectureship, American Physiological Society (2015)[35]
- Medal of Honor with Purple Ribbon (2016)[36][37]
- Asahi Prize (2017)[38]
- Keio Medical Science Prize (2018)[2]
- Person of Cultural Merit (2019)[39]
- Breakthrough Prize in Life Sciences (2023)[40]
- Clarivate Citation Laureates (2023)[41]
Personal life
Yanagisawa is married, and is a Baptist Christian since his second year of PhD.[42] He plays the flute.[6]
References
- ^ a b 餌取, 章男. ""ねむけ"の謎を解明したい" (in Japanese). Nature Japan. Archived from the original on November 4, 2022. Retrieved November 4, 2022.
- ^ a b c "柳沢 正史(やなぎさわ まさし)博士" (in Japanese). Keio Medical Science Prize. Archived from the original on November 4, 2022. Retrieved November 4, 2022.
- ^ a b c "Masashi Yanagisawa, M.D., Ph.D." (PDF). Institute of Physiology, Czech Academy of Sciences. Archived from the original (PDF) on November 3, 2022. Retrieved November 4, 2022.
- ^ Korkutata, Mustafa (September 7, 2020). "An exclusive interview with Masashi Yanagisawa from discovery of Endothelin to Orexin". Archived from the original on November 14, 2022. Retrieved November 14, 2022.
- ^ a b c "Masashi Yanagisawa Research History". Japan Science and Technology Agency. Archived from the original on November 6, 2022. Retrieved November 6, 2022.
- ^ a b "Masashi Yanagisawa". International Institute for Integrative Sleep Medicine, University of Tsukuba. Archived from the original on November 6, 2022. Retrieved November 6, 2022.
- ^ "YANAGISAWA Orphan Receptor". Japan Science and Technology Agency. Archived from the original on November 15, 2022. Retrieved November 15, 2022.
- ^ "Masashi Yanagisawa". University of Tsukuba. November 29, 2016. Archived from the original on November 15, 2022. Retrieved November 15, 2022.
- ^ "Masashi Yanagisawa, MD, PhD". Howard Hughes Medical Institute. Archived from the original on November 3, 2022. Retrieved November 3, 2022.
- ^ "Press release" (Press release). Nobel Prize. Archived from the original on November 8, 2022. Retrieved November 8, 2022.
- ^ Vane, John (1990). "Endothelins come home to roost" (PDF). Nature. 348 (6303): 673. Bibcode:1990Natur.348..673V. doi:10.1038/348673a0. PMID 2175394. S2CID 4351182. Retrieved November 8, 2022.
- ^ Yanagisawa, Masashi; Kurihara, Hiroki; Kimura, Sadao; Tomobe, Yoko; Kobayashi, Mieko; Mitsui, Youji; Yazaki, Yoshio; Goto, Katsutoshi; Masaki, Tomoh (1988). "A novel potent vasoconstrictor peptide produced by vascular endothelial cells". Nature. 332 (6163): 411–415. Bibcode:1988Natur.332..411Y. doi:10.1038/332411a0. hdl:2241/1639. PMID 2451132. S2CID 4308549. Retrieved November 8, 2022.
- ^ Sakurai, Takeshi; Yanagisawa, Masashi; Takuwa, Yoh; Miyazaki, Hitoshi; Kimura, Sadao; Goto, Katsutoshi; Masaki, Tomoh (1990). "Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor". Nature. 348 (6303): 732–735. Bibcode:1990Natur.348..732S. doi:10.1038/348732a0. hdl:2241/1311. PMID 2175397. S2CID 4249387. Retrieved November 9, 2022.
- ^ Xu, Dong; Emoto, Noriaki; Giaid, Adel; Slaughter, Clive; Kaw, Semiko; deWit, Damiane; Yanagisawa, Masashi (1994). "ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1". Cell. 78 (3): 473–485. doi:10.1016/0092-8674(94)90425-1. PMID 8062389. S2CID 7872049. Retrieved November 9, 2022.
- ^ Puffenberger, Erik G.; Hosoda, Kiminori; Washington, Sarah S.; Nakao, Kazuwa; deWit, Damiane; Yanagisawa, Masashi; Chakravarti, Aravinda (1994). "A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease". Cell. 79 (7): 1257–1266. doi:10.1016/0092-8674(94)90016-7. PMID 8001158. S2CID 24894649. Retrieved November 9, 2022.
- ^ Sakurai, Takeshi; Amemiya, Akira; Ishii, Makoto; Matsuzaki, Ichiyo; Chemelli, Richard M.; Tanaka, Hirokazu; Williams, S. Clay; Richardson, James A.; Kozlowski, Gerald P.; Wilson, Shelagh; Arch, Jonathan R. S.; Buckingham, Robin E.; Haynes, Andrea C.; Carr, Steven A.; Annan, Roland S.; McNulty, Dean E.; Liu, Wu-Schyong; Terrett, Jonathan A.; Elshourbagy, Nabil A.; Bergsma, Derk J.; Yanagisawa, Masashi (1998). "Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior". Cell. 92 (4): 573–585. doi:10.1016/s0092-8674(00)80949-6. PMID 9491897.
- ^ de Lecea, L.; Kilduff, T. S.; Peyron, C.; Gao, X.-B.; Foye, P. E.; Danielson, P. E.; Fukuhara, C.; Battenberg, E. L. F.; Gautvik, V. T.; Bartlett, II, F. S.; Frankel, W. N.; van den Pol, A. N.; Bloom, F. E.; Gautvik, K. M.; Sutcliffe, J. G. (1998). "The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity". Proceedings of the National Academy of Sciences. 95 (1): 322–327. Bibcode:1998PNAS...95..322D. doi:10.1073/pnas.95.1.322. PMC 18213. PMID 9419374.
- ^ Gotter, Anthony L.; Webber, Andrea L.; Coleman, Paul J.; Renger, John J.; Winrow, Christopher J. (2012). "International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology". Pharmacological Reviews. 64 (3): 389–420. doi:10.1124/pr.111.005546. PMID 22759794. S2CID 2038246. Archived from the original on November 14, 2022. Retrieved November 14, 2022.
- ^ Chemelli, Richard M.; Willie, Jon T.; Sinton, Christopher M.; Elmquist, Joel K.; Scammell, Thomas; Lee, Charlotte; Richardson, James A.; Williams, S. Clay; Xiong, Yumei; Kisanuki, Yaz; Fitch, Thomas E.; Nakazato, Masamitsu; Hammer, Robert E.; Saper, Clifford B.; Yanagisawa, Masashi (1999). "Narcolepsy in orexin Knockout Mice: Molecular Genetics of Sleep Regulation". Cell. 98 (4): 437–451. doi:10.1016/s0092-8674(00)81973-x. PMID 10481909. S2CID 89799178.
- ^ Peyron, Christelle; Faraco, Juliette; Rogers, William; Ripley, Beth; Overeem, Sebastiaan; Charnay, Yves; Nevsimalova, Sona; Aldrich, Michael; Reynolds, David; Albin, Roger; Li, Robin; Hungs, Marcel; Pedrazzoli, Mario; Padigaru, Muralidhara; Kucherlapati, Melanie; Fan, Jun; Maki, Richard; Lammers, Gert Jan; Bouras, Constantin; Kucherlapati, Raju; Nishino, Seiji; Mignot, Emmanuel (2000). "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains". Nature Medicine. 6 (9): 991–997. doi:10.1038/79690. PMID 10973318. S2CID 18076282. Retrieved November 15, 2022.
- ^ Tanaka, Hirokazu; Yoshida, Tetsuo; Miyamoto, Norimasa; Motoike, Toshiyuki; Kurosu, Hiroshi; Shibata, Kenji; Yamanaka, Akihiro; Williams, S. Clay; Richardson, James A.; Tsujino, Natsuko; Garry, Mary G.; Lerner, Michael R.; King, David S.; O'Dowd, Brian F.; Sakurai, Takeshi; Yanagisawa, Masashi (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proceedings of the National Academy of Sciences. 100 (10): 6251–6256. Bibcode:2003PNAS..100.6251T. doi:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
- ^ Xiong, Yumei; Miyamoto, Norimasa; Shibata, Kenji; Valasek, Mark A.; Motoike, Toshiyuki; Kedzierski, Rafal M.; Yanagisawa, Masashi (2004). "Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41". Proceedings of the National Academy of Sciences. 101 (4): 1045–1050. Bibcode:2004PNAS..101.1045X. doi:10.1073/pnas.2637002100. PMC 327148. PMID 14722361.
- ^ Takayasu, Shinobu; Sakurai, Takeshi; Iwasaki, Satoshi; Teranishi, Hitoshi; Yamanaka, Akihiro; Williams, S. Clay; Iguchi, Haruhisa; Kawasawa, Yuka Imamura; Ikeda, Yukio; Sakakibara, Iori; Ohno, Kousaku; Ioka, Ryoichi X.; Murakami, Saori; Dohmae, Naoshi; Xie, Jian; Suda, Toshihiro; Motoike, Toshiyuki; Ohuchi, Takashi; Yanagisawa, Masashi; Sakai, Juro (2006). "A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice". Proceedings of the National Academy of Sciences. 103 (19): 7438–7443. Bibcode:2006PNAS..103.7438T. doi:10.1073/pnas.0602371103. PMC 1464357. PMID 16648250.
- ^ a b "柳沢 正史 Masashi Yanagisawa, MD PhD". International Institute for Integrative Sleep Medicine, University of Tsukuba. Archived from the original on November 17, 2022. Retrieved November 17, 2022.
- ^ Funato, Hiromasa; Miyoshi, Chika; Fujiyama, Tomoyuki; Kanda, Takeshi; Sato, Makito; Wang, Zhiqiang; Ma, Jing; Nakane, Shin; Tomita, Jun; Ikkyu, Aya; Kakizaki, Miyo; Hotta-Hirashima, Noriko; Kanno, Satomi; Komiya, Haruna; Asano, Fuyuki; Honda, Takato; Kim, Staci J.; Harano, Kanako; Muramoto, Hiroki; Yonezawa, Toshiya; Mizuno, Seiya; Miyazaki, Shinichi; Connor, Linzi; Kumar, Vivek; Miura, Ikuo; Suzuki, Tomohiro; Watanabe, Atsushi; Abe, Manabu; Sugiyama, Fumihiro; Takahashi, Satoru; Sakimura, Kenji; Hayashi, Yu; Liu, Qinghua; Kume, Kazuhiko; Wakana, Shigeharu; Takahashi, Joseph S.; Yanagisawa, Masashi (2016). "Forward-genetics analysis of sleep in randomly mutagenized mice". Nature. 539 (7629): 378–383. Bibcode:2016Natur.539..378F. doi:10.1038/nature20142. PMC 6076225. PMID 27806374.
- ^ Wang, Zhiqiang; Ma, Jing; Miyoshi, Chika; Li, Yuxin; Sato, Makito; Ogawa, Yukino; Lou, Tingting; Ma, Chengyuan; Gao, Xue; Lee, Chiyu; Fujiyama, Tomoyuki; Yang, Xiaojie; Zhou, Shuang; Hotta-Hirashima, Noriko; Klewe-Nebenius, Daniela; Ikkyu, Aya; Kakizaki, Miyo; Kanno, Satomi; Cao, Liqin; Takahashi, Satoru; Peng, Junmin; Yu, Yonghao; Funato, Hiromasa; Yanagisawa, Masashi; Liu, Qinghua (2018). "Quantitative phosphoproteomic analysis of the molecular substrates of sleep need". Nature. 558 (7710): 435–439. Bibcode:2018Natur.558..435W. doi:10.1038/s41586-018-0218-8. PMC 6350790. PMID 29899451.
- ^ "The 1998 Kilby Laureates". Kilby International Awards. Archived from the original on November 17, 2022. Retrieved November 17, 2022.
- ^ Emerson, Eva (May 15, 1998). "Pasarow awards honor three outstanding researchers". University of Southern California. Archived from the original on November 19, 2022. Retrieved November 19, 2022.
- ^ "The Novartis Award For Hypertension Research". American Heart Association. Archived from the original on November 17, 2022. Retrieved November 17, 2022.
- ^ "John J. Abel Award". American Society for Pharmacology and Experimental Therapeutics. Archived from the original on November 19, 2022. Retrieved November 19, 2022.
- ^ "Prize recipients: Jacobæus Prize". Novo Nordisk Foundation. Archived from the original on November 19, 2022. Retrieved November 19, 2022.
- ^ "Bristol-Myers Squibb 'Freedom to Discover' Awards". Oncology Times. 25 (22): 58. 2003. doi:10.1097/01.COT.0000290764.24899.c9. S2CID 220570423. Archived from the original on November 20, 2022. Retrieved November 20, 2022.
- ^ "Masashi Yanagisawa". National Academy of Sciences. Archived from the original on November 22, 2022. Retrieved November 22, 2022.
- ^ "The Ulf von Euler lecture". Karolinska Institute. Archived from the original on May 26, 2022. Retrieved May 26, 2022.
- ^ "Sleep Medicine Professional Wins American Physiological Society Award". Sleep Review. April 10, 2015. Archived from the original on November 20, 2022. Retrieved November 20, 2022.
- ^ "柳沢正史機構長が紫綬褒章を受章" (in Japanese). International Institute for Integrative Sleep Medicine, University of Tsukuba. April 28, 2016. Archived from the original on November 22, 2022. Retrieved November 22, 2022.
- ^ "平成28年春の褒章受章者名簿 在日外国人" (PDF) (in Japanese). Cabinet Office, Government of Japan. Archived from the original (PDF) on November 22, 2022. Retrieved November 22, 2022.
- ^ "柳沢正史教授の2017年度朝日賞受賞が決定" (in Japanese). University of Tsukuba. January 4, 2018. Archived from the original on January 29, 2018. Retrieved January 29, 2018.
- ^ "令和元年度 文化功労者". Ministry of Education, Culture, Sports, Science and Technology. November 3, 2019. Archived from the original on January 18, 2022. Retrieved January 18, 2022.
- ^ "Masashi Yanagisawa". Breakthrough Prize in Life Sciences. Archived from the original on November 3, 2022. Retrieved November 3, 2022.
- ^ "Clarivate Citation Laureates 2023_Physiology or Medicine". Clarivate Citation Laureates. Archived from the original on September 19, 2023. Retrieved September 19, 2023.
- ^ 坂本, 直子 (October 7, 2018). "【インタビュー】柳沢正史さん(後編) 科学の発見は「何とかなる」という信仰に支えられている". Christian Press (in Japanese). Archived from the original on November 4, 2022. Retrieved November 4, 2022.