Protein-coding gene in the species Homo sapiens
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) , also known as BAMBI , is a protein which in humans is encoded by the BAMBI gene .[ 5] [ 6]
Function
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta ) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[ 5]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000095739 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024232 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b "Entrez Gene: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)" .
^ Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW, Bloemers HP (February 1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts" . Int. J. Cancer . 65 (4): 460–5. doi :10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E . PMID 8621228 .
Further reading
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Lin Z, Gao C, Ning Y, et al. (2008). "The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling" . J. Biol. Chem . 283 (48): 33053–8. doi :10.1074/jbc.M804039200 . PMC 2662247 . PMID 18838381 .
Sekiya T, Oda T, Matsuura K, Akiyama T (2004). "Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling". Biochem. Biophys. Res. Commun . 320 (3): 680–4. doi :10.1016/j.bbrc.2004.06.017 . PMID 15240101 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Fritzmann J, Morkel M, Besser D, et al. (2009). "A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential" . Gastroenterology . 137 (1): 165–75. doi :10.1053/j.gastro.2009.03.041 . PMID 19328798 .
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res . 259 (1): 239–46. doi :10.1006/excr.2000.4948 . PMID 10942595 .
Khin SS, Kitazawa R, Win N, et al. (2009). "BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer" . Int. J. Cancer . 125 (2): 328–38. doi :10.1002/ijc.24318 . PMID 19326429 . S2CID 32084443 .
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis . 8 : 196–204. PMID 12107411 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Sekiya T, Adachi S, Kohu K, et al. (2004). "Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells" . J. Biol. Chem . 279 (8): 6840–6. doi :10.1074/jbc.M310876200 . PMID 14660579 .
Togo N, Ohwada S, Sakurai S, et al. (2008). "Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer" . World J. Gastroenterol . 14 (31): 4880–8. doi :10.3748/wjg.14.4880 . PMC 2739940 . PMID 18756595 .
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10" . Nature . 429 (6990): 375–81. Bibcode :2004Natur.429..375D . doi :10.1038/nature02462 . PMID 15164054 .
Zhang Z, Henzel WJ (2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites" . Protein Sci . 13 (10): 2819–24. doi :10.1110/ps.04682504 . PMC 2286551 . PMID 15340161 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
Degen WG, Weterman MA, van Groningen JJ, et al. (1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts" . Int. J. Cancer . 65 (4): 460–5. doi :10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E . PMID 8621228 .
External links
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
Type I
ALK1 (ACVRL1 )ALK2 (ACVR1A )ALK3 (BMPR1A )ALK4 (ACVR1B )ALK5 (TGFβR1 )ALK6 (BMPR1B )
Agonists: BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 15 )
Radotermin
ALK7 (ACVR1C )
Type II
TGFβR2 BMPR2 ACVR2A (ACVR2 )
Agonists: Activin (A , B , AB )
BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 11 (BMP11) , 15 )
Myostatin (GDF8)
Nodal
Radotermin
ACVR2B
Agonists: Activin (A , B , AB )
BMP (2 , 4 , 6 , 7 )
Dibotermin alfa
Eptotermin alfa
GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) )
Myostatin (GDF8)
Nodal
Osteogenin (BMP3, BMP3A)
Radotermin
AMHR2 (AMHR )
Type III
Unsorted