Rosetta Biosoftware Integrates Affymetrix GeneChip Operating Software with the Rosetta Resolver System Version 5.0

Rosetta Biosoftware today announced the integration of the Affymetrix GeneChip(R) Operating Software (GCOS) with version 5.0 of the Rosetta Resolver(R) gene expression data analysis system. The integration between the two systems will ease collaboration efforts between scientists, improve productivity in high-throughput gene expression laboratories, and seamlessly allow advanced data interpretation and data mining of results from Affymetrix GeneChip brand microarrays.

“We have developed a tight integration between the Affymetrix GeneChip platform and version 5.0 of the Rosetta Resolver system in direct response to our customers’ desire to enhance the flexibility of their research environment,” said Yelena Shevelenko, vice president and general manager of Rosetta Biosoftware. “Our work with Affymetrix furthers our commitment to empower users with the most effective analysis tools and formats for gene expression analysis.”

Researchers working with GeneChip microarray data can utilize the visualization and statistical analysis features within the Resolver system by directly importing results from the Affymetrix core software into the Resolver application. The interoperability between the two systems allows efficient and scalable data management, and enables Affymetrix users to leverage the robust analytical capabilities of the Resolver system without inconvenient data format conversions.

“Through our Developer’s Network, Affymetrix actively supports our customers, our partners, and the academic community in their efforts to bring new value-added capabilities to the Affymetrix GeneChip platform,” said Steve Lincoln, Vice-President of Informatics at Affymetrix. “This new integrated version of the Rosetta Resolver system provides a powerful, enterprise-class solution for our customers, further enabling their use of Affymetrix GeneChip microarrays in emerging high-throughput application areas, such as predictive toxicology and translational medicine.”

About the Rosetta Resolver System

The Rosetta Resolver system is a high-capacity data storage, retrieval and analysis solution for gene expression data. The system is ideal for life science research organizations that need to assess compound specificity or toxicity, identify new genes or therapeutic targets or compare and analyze large databases of expression profiles. The Rosetta Resolver system combines flexibility and ease of use with high-performance algorithms to produce an enterprise solution for rapid analysis of gene expression data. The Rosetta Resolver system can accept and analyze data from a wide variety of expression profiling formats, including Affymetrix GeneChip, Agilent DNA and GE Healthcare Biosciences CodeLink microarrays, and applies Rosetta Biosoftware’s proprietary error models to yield quality statistics for every gene expression measurement within the system. These statistics are automatically leveraged by Rosetta Resolver system analysis tools for optimal results. The system is also highly customizable, and includes a Software Development Kit (SDK) for extension and customization.

Life science research organizations that have licensed the Rosetta Resolver system include many of the top pharmaceutical companies in the world, such as Aventis Pharmaceuticals, Bristol-Myers Squibb, GlaxoSmithKline and Merck & Co., Inc., as well as premier academic institutions such as the Harvard University Center for Genomics Research. The Rosetta Resolver system is distributed exclusively by Agilent Technologies. Additional information about the Rosetta Resolver system can be found on the Rosetta Biosoftware Web site at www.rosettabio.com .

About Rosetta Biosoftware

Rosetta Biosoftware is a leading provider of enterprise bioinformatics solutions for life science research. Its enterprise software solutions, including the Rosetta Resolver and Rosetta Luminator gene-expression data analysis systems, empower life scientists with advanced, scalable, and easy-to-use analysis platforms that accelerate discovery research. Rosetta Biosoftware is a business unit of Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc. (NYSE:MRK). More information about Rosetta Biosoftware is available at www.rosettabio.com .

Rosetta Resolver is a registered trademark of Rosetta Inpharmatics LLC.