Tips on Implementing, Maintaining and Validating Empower 3 Software Custom Fields to Maximize Data Integrity
Waters Empower 3 software is a chromatography data system (CDS) that links to chromatographic instruments to help facilitate management of chromatography test results through data acquisition, processing, reporting and distribution. Waters Empower 3 generates lots of data with complex calculations and detailed reports and has several tools that address compliance and data integrity concerns such as electronic signatures and audit trails.
Given that Waters Empower 3 typically generates large amounts of data, transcribing the data from Empower 3 to an external system can present huge risks from a data integrity perspective. As a result, scientific laboratories are looking for ways to maximize their results output from Empower and ideally utilize this system as their only solution for chromatographic results.
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MELLODDY Consortium Employs Federated Learning and Blockchain to Enhance AI Drug Discovery
A new consortium of pharmaceutical, technology and academic partners is hoping to improve collaboration and competitive data sharing among pharmaceutical companies in ways that would address IP concerns. Utilizing blockchain and federated learning technologies, the MELLODDY (Machine Learning Ledger Orchestration for Drug Discovery) Consortium aims to use deep learning methods on the chemical libraries of 10 pharma companies to create a modeling platform that can more quickly and accurately predict promising compounds for development, all without sacrificing the data privacy of the participating companies.
Over the last few years, pharma and biotech companies have been adopting artificial intelligence (AI) and big data approaches, particularly machine learning and deep learning, in hopes that these technologies will change the way the industry discovers, develops, and manufactures medicines. Advances in computational power have opened up the possibility of creating digital models utilizing machine learning that can dramatically accelerate innovation and yield inexpensive predictions from expensive data.
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Supporting Life Science IT with Laboratory Informatics as a Service
Modern Life Science laboratories typically utilize many different applications and legacy systems to manage their workflows and data, but unfortunately, there is often very little integration between these systems. As such, managing all the IT dependencies in these modern labs is a significant undertaking.
Today’s Life Science IT professionals need to be both knowledgeable across scientific domains and experts at the informatics. The reality is that creating the necessary integrated laboratory ecosystem and the subsequent support, maintenance, and extension of it is such a significant undertaking that only large companies with sufficient budget and resources have been able to attempt it.
With the rate of data generation increasing exponentially in Life Science R&D laboratories, there has never been a time when laboratories are so tightly coupled to informatics systems and scientists so dependent on IT. In this challenging environment, IT professionals often get bogged down in supporting current infrastructure instead of developing and maintaining strategic roadmaps to be ready for future demand. In order to future-proof your lab, a third-party informatics vendor with industry experience and expertise in laboratory informatics systems can be a valuable partner to your organization by providing Laboratory Informatics as a Service (LIaaS).
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Thermo Fisher Scientific Introduces NGS-Based Solution for Expanded Carrier Screening Research
Thermo Fisher Scientific today introduced a new next-generation sequencing (NGS)-based solution that enables reproductive health researchers to more efficiently analyze a broad range of key genetic markers with an end-to-end workflow.
Hologic Launches New Scalable Options for Panther System in the United States and Europe
New product offerings within the Panther Scalable Solutions (PSS) portfolio are now commercially available in the United States and Europe, Hologic (Nasdaq: HOLX) announced today. These new optional configurations, which represent Hologic’s next generation of molecular diagnostics innovation, will allow laboratories to scale their instrumentation to meet testing demands in both their current workflow and their future growth plans.LabKey Releases Sample Management Software with Data Integration and Workflow Features
LabKey has released Sample Manager, sample management software developed to bring greater ease, efficiency and insight to sample processing within laboratories.Bio-Rad Bundles FCS Express Flow Cytometry Analysis Software with the ZE5 Cell Analyzer
Bio-Rad Laboratories, Inc. announced that its ZE5 Cell Analyzer now comes with FCS Express flow cytometry analysis software from De Novo Software. By providing FCS Express with the ZE5 Cell Analyzer, Bio-Rad extends the analytical capabilities of the instrument, providing users a complete flow cytometry workflow solution.New Director of Technical Services, North America For Autoscribe Informatics
Scott Krieger has joined Autoscribe Informatics as Director of Technical Services, North America. Autoscribe Informatics provides the industry leading configurable Matrix Gemini Laboratory Information Management System (LIMS). Scott will be bringing his extensive leadership experience to the organization, working closely with the Technical Services team to streamline the implementation and support processes as the company continues to grow.
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Honeywell and Bigfinite will Collaborate to Drive Digital Transformation with Next-Generation Platform for Biotech and Pharma Industries
Honeywell today announced its collaboration with Bigfinite focused on delivering innovative solutions and platforms for the life sciences industry. Using artificial intelligence and machine learning, the collaboration will focus on delivering new technology to help enable faster delivery of medical therapies to the biotech and pharma industries.Laboratory Informatics Weekly Update – Volume 18, Issue 6
February 11, 2020 Laboratory Informatics Weekly Update Volume 18, Issue 6 In This Issue Upcoming Webinars 02/19/2020 - Webinar: Operationalizing Business Associate Risk Management for Compliance with HIPAA Regulation02/19/2020 - Webinar: LIMS Instrument Interfacing – The Times They Are A-Changing02/27/2020 - Astrix Webinar – Best Practices for Conducting Data Integrity Assessments03/25/2020 - Webinar: LIMS Configuration 101 Featured Books LIMSjournal - Winter 2019 Journal Articles Universal LIMS-based platform for the automated processing of cell-based assaysIn this brief article by Schmieder et al., the authors provide an example of applying laboratory informatics to research activities for drug discovery and personalized medicine.…Universal LIMS-based platform for the automated processing of cell-based assays
In this brief article by Schmieder et al., the authors provide an example of applying laboratory informatics to research activities for drug discovery and personalized medicine. In particular, the authors look at the in vitro nephrotoxicity assay and the use of transepithelial electrical resistance (TEER) to evaluate the barrier function of cellular layers. Citing issues such as the significant multi-step processes involved with this type of testing, the authors attempt to demonstrate how a laboratory information management system (LIMS), laboratory execution system (LES), and automation standards such as SiLA can be used together to decrease the workflow complexity of such cell-based assays.
Leveraging conservation action with open‐source hardware
Researchers in a wide variety of fields are gradually realizing the benefits of open-source hardware (OSH) in their scientific activities, though not easily. Projects associated with OSH often fail for lack of technological know-how, long-term funding, and strong organization. In this 2019 article, Hill et al. suggest the benefits of "a provisional framework for developing and sustaining the life cycle of not‐for‐profit OSH," in this case applying it to their biological and conservation science. The authors describe their six-phase framework spread across two management teams, one for engineering and one for logistics (with both sharing social media and outreach duties). They present as a case study the AudioMoth project for the development of a low-cost, full-spectrum acoustic logger, which was largely crowd-sourced. They conclude by emphasizing the importance of frameworks such as theirs, stating that without them "existing OSH will continue to have short life spans, and remain out of reach for the majority of conservation biologists." More broadly, they also note the need "to push access to OSH toward communities outside of the pockets of wealth and high opportunity that the framework may initially serve."
National Institutes of Health (NIH) Research and Upcoming Events – February 2020
As part of the U.S. Department of Health and Human Services, the National Institutes of Health (NIH) is our nation’s medical research agency and strives to make important discoveries that improve health and save lives. Founded in 1870, the NIH conducts its own scientific research through its Intramural Research Program (IRP), which supports approximately 1,200 principal investigators and more than 4,000 postdoctoral fellows conducting basic, translational and clinical research. The NIH also provides biomedical research funding for non-NIH research facilities via its Extramural Research Program, investing nearly $39.2 billion in external medical research in 2019.
In a study conducted by the Nature Index in 2019, the NIH ranked #2 in the world in terms of published scientific papers, behind only Harvard University in Boston. In this blog, we will highlight recent ground-breaking research that has been conducted through the NIH IRP, while also providing links to upcoming NIH events designed to keep researchers abreast of the latest discoveries.
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Business Benefits of a LIMS
Ensuring regulatory compliance, reducing errors, streamlining workflows and enabling growth through the introduction, consolidation and integration of IT systems will ultimately pay dividends for the business and help achieve a competitive advantage. However, for many reasons including lack of resources, no formal business plan or the difficulty of articulating the potential business benefits, laboratories often struggle to drive the introduction and modernization of IT solutions in their laboratories.
Autoscribe Informatics works with companies worldwide to improve business efficiency. Our Matrix Gemini Laboratory Information Management System (LIMS) drives consolidation, improves data integrity and increases laboratory efficiency. Laboratory process automation and workflow management can reduce transcription errors, improve turn-around times, and increase resource utilization; and these are just a few of the business benefits associated with adopting a LIMS.
